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Compare Entresto vs. Farxiga

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Entresto (sacubitril / valsartan)
    Farxiga (dapagliflozin)
  • Entresto (sacubitril / valsartan)
    Farxiga (dapagliflozin)

  • Summary of Entresto vs. Farxiga

    Summary for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Prescription only

    Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.

    Summary for SGLT2 inhibitor
    Prescription only

    Farxiga, the brand name for dapagliflozin, is used together with a nutritious diet and exercise plan to lower blood sugar levels in people 10 years and older with Type 2 diabetes. It can also help lower the risk of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Farxiga (dapagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's taken by mouth once a day. Some side effects include yeast infections, urinating more often, and weight loss.

  • Indications of Entresto vs. Farxiga

    Indications for
    •Heart failure in people ages 1 year or older
    Indications for
    •Type 2 diabetes (in addition to diet and exercise) in people age 10 and over
    •Lowering the risk of hospitalization for heart failure in adults with Type 2 diabetes and heart disease
    •Lowering the risk of hospitalization and death due to heart problems in people with heart failure
    •Lowering the risk of worsening kidney problems, hospitalization for heart failure, and death due to heart problems in adults with chronic kidney disease (CKD)

  • Pros and Cons of Entresto vs. Farxiga

    Pros and Const for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Pros
    •First-choice treatment for some people with heart failure
    •Can lower the risk of hospital visits related to heart failure in adults
    •Combines two medications into one pill for convenience
    •Available as tablets, oral pellets, or a prepared oral solution
    Cons
    •Need to take twice daily
    •Can cause dizziness and low blood pressure
    •Not safe during pregnancy
    Pros and Const for SGLT2 inhibitor
    Pros
    •Taken only once daily
    •Low risk of causing low blood sugar when taken by itself
    •Can take with other diabetes medications
    Cons
    •Raises risk of yeast infections and urinary tract infections (UTIs)
    •Not available as a liquid
    •Not recommended during the second and third trimesters of pregnancy

  • Common Side Effects of Entresto vs. Farxiga

    Common Side Effects for
    •Low blood pressure (18%)
    •High potassium levels (12%)
    •Cough (9%)
    •Dizziness (6%)
    •Kidney problems (5%)
    Common Side Effects for
    •Vaginal yeast infection in females (7-8%)
    •Nose and throat infection (6-7%)
    •Urinary tract infection (UTI, 4-6%)

  • Warnings of Entresto vs. Farxiga

    Common Side Effects for
    •Not safe during pregnancy
    •Swelling of face, tongue, or throat (angioedema)
    •Low blood pressure
    •Kidney problems
    •High potassium levels
    Common Side Effects for
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with other diabetes medications

  • Prices with our coupons for Entresto vs. Farxiga

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