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Compare Entresto vs. Farxiga

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Entresto (sacubitril/valsartan) and Farxiga (dapagliflozin) are both medications used to help manage heart failure, but they belong to different medication classes and have distinct uses. Entresto is an angiotensin receptor-neprilysin inhibitor (ARNI) specifically approved for treating heart failure in people ages 1 year and older. It combines two medications, sacubitril and valsartan, to help relax blood vessels and improve heart function. Farxiga, on the other hand, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor primarily used to lower blood sugar in people with Type 2 diabetes. It also helps reduce the risk of hospitalization and death in adults with heart failure or chronic kidney disease. Entresto is taken twice daily, while Farxiga is taken once daily. Entresto is not available as a generic, whereas Farxiga has a lower-cost generic option. Common side effects of Entresto include low blood pressure and dizziness, while Farxiga may cause yeast infections, urinary tract infections, and increased urination. Entresto should not be taken with angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors, while Farxiga can interact with other diabetes medications and with diuretics.

Entresto (sacubitril / valsartan)
Farxiga (dapagliflozin)
Entresto (sacubitril / valsartan)
Farxiga (dapagliflozin)
Summary of Entresto vs. Farxiga
Summary for Angiotensin receptor-neprilysin inhibitor (ARNI)
Prescription only
Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.
Summary for SGLT2 inhibitor
Prescription only
Farxiga, the brand name for dapagliflozin, is used together with a nutritious diet and exercise plan to lower blood sugar levels in people 10 years and older with Type 2 diabetes. It can also help lower the risk of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Farxiga (dapagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's taken by mouth once a day. Some side effects include yeast infections, urinating more often, and weight loss.
Indications of Entresto vs. Farxiga
Indications for

•Heart failure in people ages 1 year or older

Indications for

•Type 2 diabetes (in addition to diet and exercise) in people age 10 and over

•Lowering the risk of hospitalization for heart failure in adults with Type 2 diabetes and heart disease

•Lowering the risk of hospitalization and death due to heart problems in people with heart failure

•Lowering the risk of worsening kidney problems, hospitalization for heart failure, and death due to heart problems in adults with chronic kidney disease (CKD)
Pros and Cons of Entresto vs. Farxiga
Pros and Const for Angiotensin receptor-neprilysin inhibitor (ARNI)
Pros

•First-choice treatment for some people with heart failure

•Can lower the risk of hospital visits related to heart failure in adults

•Combines two medications into one pill for convenience

•Available as tablets, oral pellets, or a prepared oral solution

Cons

•Need to take twice daily

•Can cause dizziness and low blood pressure

•Not safe during pregnancy

Pros and Const for SGLT2 inhibitor
Pros

•Taken only once daily

•Low risk of causing low blood sugar when taken by itself

•Can take with other diabetes medications

Cons

•Raises risk of yeast infections and urinary tract infections (UTIs)

•Not available as a liquid

•Not recommended during the second and third trimesters of pregnancy
Common Side Effects of Entresto vs. Farxiga
Common Side Effects for

•Low blood pressure (18%)

•High potassium levels (12%)

•Cough (9%)

•Dizziness (6%)

•Kidney problems (5%)

Common Side Effects for

•Vaginal yeast infection in females (7-8%)

•Nose and throat infection (6-7%)

•Urinary tract infection (UTI, 4-6%)
Warnings of Entresto vs. Farxiga
Common Side Effects for

•Not safe during pregnancy

•Swelling of face, tongue, or throat (angioedema)

•Low blood pressure

•Kidney problems

•High potassium levels

Common Side Effects for

•Ketoacidosis

•Low fluids in the body (leading to low blood pressure or dehydration)

•Genital and urinary tract infections

•Low blood sugar (hypoglycemia) when used with other diabetes medications
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Compare Entresto vs. Farxiga

Key takeaways

Summary of Entresto vs. Farxiga

Indications of Entresto vs. Farxiga

Pros and Cons of Entresto vs. Farxiga

Common Side Effects of Entresto vs. Farxiga

Warnings of Entresto vs. Farxiga

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