Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Entresto vs. Losartan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Sacubitril / valsartan (Entresto) and losartan (Cozaar) are both medications used to treat heart-related conditions, but they belong to different medication classes. Sacubitril / valsartan is an angiotensin receptor-neprilysin inhibitor (ARNI) and is specifically approved for treating heart failure in people ages 1 year and older. Losartan, on the other hand, is an angiotensin II receptor blocker (ARB) and is primarily used to lower high blood pressure, reduce the risk of stroke, and slow kidney problems in people with Type 2 diabetes. Sacubitril / valsartan is taken twice daily and is not available as a generic, while losartan is taken once daily and is available as a lower-cost generic. Common side effects of sacubitril / valsartan include low blood pressure, high potassium levels, and dizziness, whereas losartan may cause dizziness, fatigue, and upper respiratory infections. Both medications can raise potassium levels, so you should avoid taking them with other medications that do the same. Additionally, neither medication should be taken with other ARBs or angiotensin-converting enzyme (ACE) inhibitors due to the risk of angioedema.

  • Entresto (sacubitril / valsartan)
    Losartan (Cozaar)
  • Entresto (sacubitril / valsartan)
    Losartan (Cozaar)

  • Summary of Entresto vs. Losartan

    Summary for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Prescription only

    Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.

    Summary for ARB
    Prescription only

    Losartan, also known by the brand name Cozaar, is a first-choice medication that's used to lower blood pressure. It's also shown to protect against stroke in certain people. In addition, this medication can slow down the worsening of kidney problems in certain people with diabetes. Losartan (Cozaar) belongs to the drug class called angiotensin II receptor blockers (ARBs). This medication is taken by mouth once daily and is available as a lower-cost generic. Side effects can include dizziness, fatigue, and upper respiratory infections.

  • Indications of Entresto vs. Losartan

    Indications for
    •Heart failure in people ages 1 year or older
    Indications for
    •High blood pressure
    •Lower the risk of stroke in people with high blood pressure who have a thickened heart (left ventricular hypertrophy)
    •Slow down the worsening of kidney problems in people with Type 2 diabetes and high blood pressure

  • Pros and Cons of Entresto vs. Losartan

    Pros and Const for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Pros
    •First-choice treatment for some people with heart failure
    •Can lower the risk of hospital visits related to heart failure in adults
    •Combines two medications into one pill for convenience
    •Available as tablets, oral pellets, or a prepared oral solution
    Cons
    •Need to take twice daily
    •Can cause dizziness and low blood pressure
    •Not safe during pregnancy
    Pros and Const for ARB
    Pros
    •A first-choice blood pressure medication, including for those with heart failure, diabetes, and kidney problems
    •Taken once per day
    •Can be taken by children as young as 6 years old
    •Works similarly to angiotensin-converting enzyme (ACE) inhibitors, but with fewer side effects, like cough and swelling
    Cons
    •Might cause dizziness
    •Might not work as well for Black people as other blood pressure medications do
    •Not safe to use during pregnancy
    •Can interact with medications like lithium and nonsteroidal anti-inflammatory drugs (NSAIDs)

  • Common Side Effects of Entresto vs. Losartan

    Common Side Effects for
    •Low blood pressure (18%)
    •High potassium levels (12%)
    •Cough (9%)
    •Dizziness (6%)
    •Kidney problems (5%)
    Common Side Effects for
    •Upper respiratory infection (e.g., common cold; 8%)
    •Dizziness (3%)
    •Stuffy nose (2%)
    •Back pain (2%)

  • Warnings of Entresto vs. Losartan

    Common Side Effects for
    •Not safe during pregnancy
    •Swelling of face, tongue, or throat (angioedema)
    •Low blood pressure
    •Kidney problems
    •High potassium levels
    Common Side Effects for
    •Harm to unborn baby
    •Low blood pressure
    •Kidney damage
    •High potassium levels

  • Prices with our coupons for Entresto vs. Losartan

    Learn more about Entresto
    Learn more about Losartan

Compare other Heart Failure and Hypertension drugs

Entresto vs FarxigaEntresto vs JardianceEntresto vs LisinoprilEntresto vs LosartanEntresto vs RanexaEntresto vs ValsartanVasotec vs EntrestoVerquvo vs EntrestoBrenzavvy vs JardianceFarxiga vs JardianceGlucovance vs JardianceGlyxambi vs JardianceInpefa vs JardianceJanuvia vs JardianceJardiance vs ActosJardiance vs AfrezzaJardiance vs GlimepirideJardiance vs GlipizideJardiance vs GlucotrolJardiance vs GlyburideJardiance vs InvokametJardiance vs InvokanaJardiance vs JanumetJardiance vs MetaglipJardiance vs MetforminJardiance vs MounjaroJardiance vs OnglyzaJardiance vs OzempicJardiance vs PrecoseJardiance vs Synjardy
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.