Angiotensin-receptor-neprilysin-inhibitors (ARNIs) are used to treat and prevent worsening of heart failure. ARNIs are combination medications made up of an angiotensin-receptor blocker (ARB) and a neprilysin inhibitor. They work together in different ways to relax blood vessels and to lower sodium and fluid levels in the body. These medications are available in oral forms, including tablets and sprinkles. Examples include sacubitril/valsartan (Entresto).