How Much Is Entresto Without Insurance?

Entresto is a prescription-only medication that contains two active ingredients: sacubitril (a neprilysin inhibitor) and valsartan (an angiotensin II receptor blocker, or ARB). It’s FDA approved to treat heart failure in adults and children ages 1 and older and is currently the only medication in its class.

Brand-name and generic versions of Entresto are available as an oral tablet that’s taken twice daily. The typical starting dosage for adults is 49 mg/51 mg twice a day. If tolerated, your prescriber may increase your dosage to 97 mg/103 mg twice daily, which is considered the ideal maintenance dosage for most adults.

For children, the twice-daily doses are based on body weight. Children who can’t swallow tablets or weigh less than 88 lbs (40 kg) can take Entresto Sprinkle capsules. These capsules can be opened, and their contents can be mixed with soft foods, such as applesauce. Pharmacists can also prepare an oral liquid from Entresto tablets if needed.

Out-of-pocket costs for Entresto vary based on several factors, such as insurance coverage and the version of the medication being filled. But you may be able to lower your costs by using a GoodRx discount or the manufacturer copay savings card.

How much does Entresto cost?

Without insurance or discounts, 60 tablets of brand-name Entresto 97 mg/103 mg cost an average of $862.53. The generic version costs an average of $501.12 for the same quantity, form, and dose. What you’ll actually pay for your prescription depends on several factors, including your dose, the pharmacy, and whether you use a discount.

Here’s a look at the average retail price for brand-name and generic Entresto at various pharmacies.

Disclosure

Entresto (Sacubitril/Valsartan)

Avg retail price

$750.22(Save 93.37%)

GoodRx discount

$49.72

See all discounts

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GoodRx discounts can help you pay less for your prescription.

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What factors affect the cost of Entresto?

The cost of Entresto depends on several factors, including:

• Location: Where you live affects your prescription costs. GoodRx research shows that people living in Little Rock, Arkansas, often pay higher prescription costs, while those in Denver tend to see lower prices.

• Pharmacy: Prescription prices can vary among retailers, even those in the same neighborhood.

• Generic vs. brand name: The generic version of Entresto typically costs much less than the brand-name option.

• Insurance: Most insurance plans cover Entresto. But you may still have out-of-pocket costs, including deductibles, copays, or coinsurance. The tier in which Entresto is placed on your plan’s formulary can also affect your costs.

• Dose: Your prescribed dose may be lower if you have certain medical conditions, like kidney or liver problems. This can affect what you pay.

• Discounts: Using the manufacturer copay savings card or a GoodRx discount could lower what you pay for Entresto.

Does insurance cover Entresto?

Entresto is widely covered by all insurance types, including Affordable Care Act (ACA) marketplace, commercial, Medicare, and Medicaid plans.

Prior authorization requirements vary by plan type. More than half of covered Medicaid enrollees and about 4 in 10 ACA plan members need to get prior authorization for coverage. People with ACA plans are most likely to be subject to step therapy rules, which affect about 1 in 5 enrollees. Step therapy is when you’re required to try other, usually lower-cost options first. 

To understand your specific coverage details and costs, check your health plan’s list of covered medications, known as a formulary, or contact your insurer directly.

How different insurance plans cover Entresto

The table below breaks down the percentage of enrollees who have coverage for Entresto by insurance type. It also shows the likelihood of having prior authorization and step therapy requirements.

EXPERT PICKS: WHAT TO READ NEXT

• Can you use your HSA to pay for Entresto? Yes, here’s how to use your health savings account (HSA) to help pay for Entresto (sacubitril / valsartan) and other eligible expenses.

• There are ways to save on your prescription costs. Use these money-saving tips to lower your out-of-pocket costs for prescription medications.

• Entresto side effects: Pharmacists explain Entresto side effects and share tips on how to manage them.

Source: Managed Markets Insight & Technology, LLC™, as of September 11, 2025. (See methodology below.)

Here are a few steps you can take if your insurance doesn’t cover Entresto:

• Check if you’re eligible for financial help through the manufacturer’s copay savings program, which is discussed below.

• Talk to your prescriber about the generic version of Entresto.

• Submit a formulary exception request for Entresto to your insurance plan. Your prescriber may need to provide certain documentation, including a letter of medical necessity explaining why you need this specific medication.

• If the formulary exception is denied, appeal the decision.

• During the next open enrollment, shop around for an insurance plan that offers better coverage for your medications.

Ways to save on Entresto

Whether or not you have insurance coverage, there are ways to reduce your out-of-pocket costs for Entresto. Here are nine options to consider.

1. Save with a GoodRx discount

A GoodRx discount could lower the cost of generic or brand-name Entresto at many pharmacies. Here’s what you might pay for the medication with these savings.

To use a GoodRx discount:

• Visit www.goodrx.com or download the app.

• Type “Entresto” in the search field, then select “Find the lowest prices.”

• Choose your prescribed dose and quantity and input your location to see prices at local pharmacies.

• You can receive the discount information by text or email, or you can print it out. You can also add it to your phone’s digital wallet app.

To avoid delays, show the discount to your pharmacy staff before your prescription is filled.

2. Apply for the manufacturer copay savings card

If you’re eligible, Novartis’ Entresto Co-Pay Offer could reduce your costs to as little as $10 for a 30-, 60-, or 90-day supply.

To qualify, you must:

• Have commercial insurance that covers part of the cost of Entresto

• Not be enrolled in Medicare, Medicaid, Tricare, Veterans Affairs (VA) health benefits, or any other government-sponsored insurance program

• Live in the U.S. or Puerto Rico

You can’t use the copay card if you’re paying entirely out of pocket or if your insurance covers the full cost of Entresto. The program, which includes a copay offer, rebate, and payment card, has a total savings limit of $4,100 per calendar year. Once you reach this limit, you’re responsible for any remaining costs.

3. Try the PAN Foundation

The Patient Access Network (PAN) Foundation offers help with out-of-pocket costs for certain medications, including Entresto if you’re being treated for heart failure. When funding is available, you could receive an initial $1,200 grant, with up to $2,400 in total per year.

To qualify, you’ll need to meet the program’s income, residency, and insurance requirements. If approved, you may also be eligible for a transportation grant.

Funding opens at different times throughout the year. Check the program’s website regularly or sign up to receive availability updates.

4. Look into the Patient Advocate Foundation Co-Pay Relief program

You may be eligible for financial assistance through the Patient Advocate Foundation Co-Pay Relief program. This program helps cover out-of-pocket costs for medications and office visits.

At this time, the fund for people with heart failure isn’t open, but the program’s status can change throughout the year. So keep an eye on the organization’s website for updates.

5. Talk to your prescriber about the generic version on Entresto

Sacubitril / valsartan is the generic version of Entresto, and it typically costs less than the brand-name version. Generic medications work as well as their brand-name counterparts. So talk with your prescriber to see if the generic version of Entresto is right for you.

6. Consider Medicare assistance and payment plan programs

If you’re enrolled in Medicare, Entresto will be among the first medications to have a negotiated price under the Inflation Reduction Act beginning in 2026. This could limit your monthly cost for a 30-day supply to about $295. You may also be able to save or better manage your prescription medications costs with these two Medicare programs:

• The Extra Help program (also called the Low-Income Subsidy, or LIS) helps people with limited income and resources pay for premiums, deductibles, and medication copays. Visit the U.S. Social Security Administration’s website or call 1-800-772-1213 to check if you qualify and apply.

• The Medicare Prescription Payment Plan allows you to split your out-of-pocket medication costs into monthly payments, instead of paying all at once. While this won’t lower the total cost of Entresto, it can make your expenses more manageable. Contact your Medicare prescription medication plan to learn more and enroll.

7. Compare pharmacy prices

Pharmacy prices can vary widely, even within the same area. Search www.goodrx.com to find the best price for both brand-name and generic Entresto in your area.

8. Ask for a 90-day supply

Talk to your healthcare professional about getting a 90-day prescription for Entresto. Many pharmacies offer discounts on larger quantities of medication. And some insurance plans offer lower copays when you fill a 3-month supply instead of monthly refills. It’s worth comparing prices to see if this option could save you money.

You can also check whether your insurer’s mail-order pharmacy offers discounts for 90-day fills.

9. Consider using your tax-free dollars

If you have a health savings account (HSA), flexible spending account (FSA), or health reimbursement arrangement (HRA), you can use those funds to pay for Entresto and other qualifying medical expenses.

Keep in mind that FSA money must be used by the end of your plan year or you’ll lose it, unless your employer provides a grace period or allows you to carry over a portion. HSA funds, however, roll over each year and remain available whenever you need them.

Why trust our experts?

Written by:

Maggie Aime, MSN, RN

Maggie Aime, MSN, RN, brings health topics to life for readers at any stage of life. With over 25 years in healthcare and a passion for education, she creates content that informs, inspires, and empowers.

Edited by:

Charlene Rhinehart, CPA

Charlene Rhinehart, CPA, is a personal finance editor at GoodRx. She has been a certified public accountant for over a decade.

Reviewed by:

Christina Aungst, PharmD

Christina Aungst, PharmD, is a pharmacy editor for GoodRx. She began writing for GoodRx Health in 2019, transitioning from freelance writer to editor in 2021.

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Methodology

We obtained national prescription coverage data for each medication from Managed Markets Insight & Technology (MMIT). The data reflects health insurance coverage as of September 2025. 

We calculated the percentage of enrollees in plans that cover each medication by dividing the number of enrollees covered for the medication within a specific insurance channel (e.g., ACA, Medicare, Medicaid) by the total number of enrollees in all plans within that channel. 

We determined the percentage of enrollees in plans with a prior authorization requirement by calculating the proportion of enrollees in plans that required prior authorization for the medication within each channel.

Finally, we measured the percentage of enrollees in plans with a step therapy requirement by calculating the proportion of enrollees in plans that imposed step therapy requirements for the medication in each channel. 

These estimates, derived from national MMIT coverage data, provide insight into health insurance coverage for each medication. They take into account restrictions such as prior authorization, step therapy, and quantity limits. The percentages are expressed relative to the total number of enrollees covered by various insurance channels, including ACA plans, commercial (excluding ACA) plans, Medicare, and Medicaid (both state-run and managed care plans).