How Much Is Entresto Without Insurance?

Entresto is a prescription-only medication that contains two active ingredients: sacubitril (a neprilysin inhibitor) and valsartan (an angiotensin II receptor blocker, or ARB). It’s FDA approved to treat heart failure in adults and children ages 1 and older.

The cost of Entresto without insurance varies based on several factors. Your prescribed dose and quantity, location, and pharmacy can all affect what you pay. But you may be able to lower your costs by using a GoodRx discount.

How much does Entresto cost without insurance?

Without insurance or discounts, 60 tablets of brand-name Entresto 97 mg/103 mg cost an average of $888.71. The generic version costs an average of $498.18 for the same quantity, form, and dose. The actual price of your prescription will depend on several factors, including your dose, the pharmacy, and whether you use a discount.

Entresto is available as an oral tablet that’s taken twice daily. The typical starting dosage for adults is 49 mg/51 mg twice a day. If tolerated, your prescriber may increase your dosage to 97 mg/103 mg twice daily, which is considered the ideal maintenance dosage for most adults. Entresto tablets are available as a brand-name or generic medication.

For children, the twice-daily doses are based on body weight. Children who can’t swallow tablets or weigh less than 88 lbs (40 kg) can take Entresto Sprinkle capsules. These brand-name-only capsules can be opened, and their contents can be mixed with soft foods, such as applesauce. Pharmacists can also prepare an oral liquid from Entresto tablets if needed.

Here’s a look at the average retail prices in your area for brand-name and generic Entresto.

What factors affect the cost of Entresto?

The cost of Entresto depends on several factors, including:

• Location: Where you live affects your prescription medication costs. For example, GoodRx research shows that people living in Little Rock, Arkansas, often have higher prescription costs, while those in Denver tend to see lower prices.

• Pharmacy: Prescription medication prices can vary among retailers, even those in the same neighborhood.

• Generic versus brand-name availability: The generic version of Entresto typically costs much less than the brand-name option.

• Insurance: Most insurance plans cover Entresto. But you may still have out-of-pocket costs, including a deductible and copays or coinsurance. The tier in which Entresto is placed on your plan’s formulary (list of covered medications) can also affect your costs.

• Dose: Your prescribed dose may be lower if you have certain health issues, like kidney or liver problems. This can affect what you pay.

• Discounts: Using a GoodRx discount could lower what you pay for Entresto.

Does insurance cover Entresto?

Entresto is widely covered by insurance plans, including Affordable Care Act (ACA) marketplace, commercial, Medicare, and Medicaid plans.

Prior authorization requirements vary by plan type. More than half of covered Medicaid enrollees and about 4 in 10 ACA plan members need to get prior authorization for coverage. To get prior authorization, your prescriber will have to submit information to your insurance provider about why you need the medication.

People with ACA plans are most likely to be subject to step therapy rules, which affect about 1 in 5 enrollees. (See the table below.) Step therapy is when you’re required to try other, usually lower-cost options first.

Check your plan’s formulary and summary of benefits and coverage. These documents can help you determine if Entresto is covered and how much it may cost you. If you’re unsure, call the phone number listed on the back of your prescription insurance card.

What to do if Entresto isn’t covered by your insurance

Here are a few steps you can take if your insurance doesn’t cover Entresto:

• Use GoodRx or enroll in GoodRx Companion to help lower your costs.

• Check if you’re eligible for financial help through an independent patient assistance program. (See more on this and GoodRx savings below.)

• Talk to your prescriber about the generic version of Entresto. If the generic isn’t covered, ask your prescriber about alternatives.

• Submit a formulary exception request for Entresto to your insurance plan. Your prescriber may need to provide certain documentation, including a letter of medical necessity explaining why you need this specific medication.

• If the formulary exception is denied, appeal the decision.

• During the next open enrollment period, shop around for an insurance plan that offers better coverage for your medications.

Ways to save on Entresto

Whether or not you have insurance coverage, there are ways to reduce your out-of-pocket costs for Entresto. Here are six options to consider.

6. Tap into your HSA, FSA, or HRA

If you have a health savings account (HSA), flexible spending account (FSA), or health reimbursement arrangement (HRA), you can use those funds to pay for Entresto and other qualifying medical expenses.

Keep in mind that FSA money must be used by the end of your plan year or you’ll lose it, unless your employer provides a grace period or allows you to carry over a portion. HSA funds, however, roll over each year and remain available whenever you need them. HRA funds may or may not expire, depending on the account.

The bottom line

Without insurance or discounts, 60 tablets of brand-name Entresto (sacubitril / valsartan) 97 mg/103 mg cost an average of $888.71. The average retail price for the same quantity and dose of the generic version is $498.18. What you’ll actually pay for Entresto will depend on several factors, including your location, pharmacy, and dosage.

With a GoodRx discount, you could pay as little as $44.32 for 60 tablets of generic Entresto 97 mg/103 mg. You may be able to save even more by enrolling in GoodRx Companion. And if you’re uninsured or underinsured, you may be eligible for an independent patient assistance program.

Why trust our experts?

Written by:

Maggie Aime, MSN, RN

Maggie Aime, MSN, RN, brings health topics to life for readers at any stage of life. With over 25 years in healthcare and a passion for education, she creates content that informs, inspires, and empowers.

Edited by:

Christina Aungst, PharmD, MWC

Christina Aungst, PharmD, MWC is a senior pharmacy editor for GoodRx. She began writing for GoodRx Health in 2019.

Reviewed by:

Sheila McAdoo, PharmD

Sheila McAdoo, PharmD, is a licensed pharmacist in Virginia and New York. She has worked in the pharmacy industry for 14 years.

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Methodology

We obtained national prescription coverage data for each medication from Managed Markets Insight & Technology (MMIT). The data reflects health insurance coverage as of September 2025. 

We calculated the percentage of enrollees in plans that cover each medication by dividing the number of enrollees covered for the medication within a specific insurance channel (e.g., ACA, Medicare, Medicaid) by the total number of enrollees in all plans within that channel. 

We determined the percentage of enrollees in plans with a prior authorization requirement by calculating the proportion of enrollees in plans that required prior authorization for the medication within each channel.

Finally, we measured the percentage of enrollees in plans with a step therapy requirement by calculating the proportion of enrollees in plans that imposed step therapy requirements for the medication in each channel. 

These estimates, derived from national MMIT coverage data, provide insight into health insurance coverage for each medication. They take into account restrictions such as prior authorization, step therapy, and quantity limits. The percentages are expressed relative to the total number of enrollees covered by various insurance channels, including ACA plans, commercial (excluding ACA) plans, Medicare, and Medicaid (both state-run and managed care plans).