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Compare Entresto vs. Ranexa

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Entresto (sacubitril/valsartan) and Ranexa (ranolazine) are both prescription medications, but they treat different conditions and belong to different drug classes. Entresto is an angiotensin receptor-neprilysin inhibitor (ARNI) used to treat heart failure in people aged 1 year and older. It combines two medications, sacubitril and valsartan, to help relax blood vessels and lower blood pressure. Ranexa, on the other hand, is an antianginal medication used to treat chronic chest pain (angina). Its believed to work by changing the flow of electrolytes in the heart to help it work more efficiently, though its exact mechanism isn't fully understood. Entresto is taken twice daily and is not available as a generic, while Ranexa is also taken twice daily but is available in both brand-name and lower-cost generic forms. Entresto can cause side effects like low blood pressure and high potassium levels, whereas Ranexa can cause headache and constipation. Additionally, Ranexa is not recommended for people with serious liver problems.

  • Entresto (sacubitril / valsartan)
    Ranolazine (Ranexa)
  • Entresto (sacubitril / valsartan)
    Ranolazine (Ranexa)

  • Summary of Entresto vs. Ranexa

    Summary for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Prescription only

    Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.

    Summary for Antianginal
    Prescription only

    Ranolazine (Ranexa) is an oral medication used to treat chest pain (angina). It's usually added to other medications when they aren't working well enough. Ranolazine (Ranexa) extended-release tablets are available in brand-name and lower-cost generic forms, but the extended-release granules (Aspruzyo Sprinkle) are available as a brand-name form only.

  • Indications of Entresto vs. Ranexa

    Indications for
    •Heart failure in people ages 1 year or older
    Indications for
    •A certain type of long-term chest pain (chronic angina)

  • Pros and Cons of Entresto vs. Ranexa

    Pros and Const for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Pros
    •First-choice treatment for some people with heart failure
    •Can lower the risk of hospital visits related to heart failure in adults
    •Combines two medications into one pill for convenience
    •Available as tablets, oral pellets, or a prepared oral solution
    Cons
    •Need to take twice daily
    •Can cause dizziness and low blood pressure
    •Not safe during pregnancy
    Pros and Const for Antianginal
    Pros
    •Makes you less likely to get chest pain from exercise
    •Safe to use if you have heart failure or diabetes
    •Can take with or without food
    •Tablets available as a lower-cost generic
    •Also available as a granule formulation if you can't swallow pills or have a feeding tube
    Cons
    •Not good for treating chest pain after it's started
    •Not usually a first-choice treatment for angina
    •Typically must take twice daily
    •Can interact with several medications, including certain heart or cholesterol medications
    •Not recommended if you have serious liver problems

  • Common Side Effects of Entresto vs. Ranexa

    Common Side Effects for
    •Low blood pressure (18%)
    •High potassium levels (12%)
    •Cough (9%)
    •Dizziness (6%)
    •Kidney problems (5%)
    Common Side Effects for
    •Dizziness (6%)
    •Headache (6%)
    •Constipation (5%)
    •Nausea (4%)

  • Warnings of Entresto vs. Ranexa

    Common Side Effects for
    •Not safe during pregnancy
    •Swelling of face, tongue, or throat (angioedema)
    •Low blood pressure
    •Kidney problems
    •High potassium levels
    Common Side Effects for
    •Abnormal heart rhythm
    •Kidney problems
    •Interactions with other medications

  • Prices with our coupons for Entresto vs. Ranexa

    Learn more about Entresto
    Learn more about Ranolazine

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