Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Dapagliflozin (Farxiga) and canagliflozin (Invokana) are both medications in the sodium-glucose cotransporter 2 (SGLT2) inhibitor class, used to manage Type 2 diabetes by lowering blood sugar levels. They also help reduce the risk of heart and kidney problems in people with diabetes. However, there are some differences between them. Dapagliflozin is approved for use in children 10 years and older, while canagliflozin is only for adults. Dapagliflozin is available in both generic and brand-name forms, whereas canagliflozin is only available as a brand-name medication. The typical starting dose for dapagliflozin is 5 mg once daily, while canagliflozin starts at 100 mg once daily. Both medications can cause urinary tract infections, yeast infections, and increased urination. Both medications should be taken with caution if you are on other diabetes medications, as this can increase the risk of low blood sugar.
Farxiga (dapagliflozin)
Invokana (canagliflozin)
Farxiga (dapagliflozin)
Invokana (canagliflozin)
Summary of Farxiga vs. Invokana
Summary for SGLT2 inhibitor
Prescription only
Farxiga, the brand name for dapagliflozin, is used together with a nutritious diet and exercise plan to lower blood sugar levels in people 10 years and older with Type 2 diabetes. It can also help lower the risk of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Farxiga (dapagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's taken by mouth once a day. Some side effects include yeast infections, urinating more often, and weight loss.
Summary for SGLT2 inhibitor
Prescription only
Invokana (canagliflozin) is a medication that's used together with a healthy diet and exercise to lower blood sugar levels in adults with Type 2 diabetes. It can also lessen the chance of worsening heart and kidney problems in some people with Type 2 diabetes. This medication is taken by mouth once a day.
Indications of Farxiga vs. Invokana
Indications for
•Type 2 diabetes (in addition to diet and exercise) in people age 10 and over
•Lowering the risk of hospitalization for heart failure in adults with Type 2 diabetes and heart disease
•Lowering the risk of hospitalization and death due to heart problems in people with heart failure
•Lowering the risk of worsening kidney problems, hospitalization for heart failure, and death due to heart problems in adults with chronic kidney disease (CKD)
Indications for
•Type 2 diabetes
•Lowering the risk of major heart events (e.g., heart attack, stroke) in adults with Type 2 diabetes and heart disease
•Lowering the risk of hospitalization for heart failure, death due to heart problems, and worsening of kidney problems in certain adults with Type 2 diabetes and diabetic kidney disease
Pros and Cons of Farxiga vs. Invokana
Pros and Const for SGLT2 inhibitor
Pros
•Taken only once daily
•Low risk of causing low blood sugar when taken by itself