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Compare Trulicity vs. Wegovy

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Trulicity (dulaglutide) and Wegovy (semaglutide) are both GLP-1 receptor agonists injected once a week and both help lower the risk of heart problems. However, they have different FDA-approved uses. Trulicity is approved for managing Type 2 diabetes in people 10 years and older and for reducing heart-related risks in adults with Type 2 diabetes. Wegovy, on the other hand, is approved for long-term weight management in adults and children 12 years and older with certain BMI criteria and also for reducing heart risks in adults with heart disease and a larger body size. Both are only available as a branded medication. Common side effects for both include nausea and stomach pain, but Wegovy tends to cause more nausea thanTrulicity. Both medications carry a risk of thyroid cancer and pancreatitis, and neither are recommended if you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2.

  • Trulicity (dulaglutide)
    Wegovy (semaglutide)
  • Trulicity (dulaglutide)
    Wegovy (semaglutide)

  • Summary of Trulicity vs. Wegovy

    Summary for GLP-1 agonist
    Prescription only

    Trulicity (dulaglutide) is a glucagon-like peptide-1 (GLP-1) agonist that helps control blood sugar in people 10 years and older with Type 2 diabetes. It's also approved to lower the risk of heart problems like heart attacks, strokes, and heart-related death in certain adults with Type 2 diabetes. The medication is injected under the skin once a week. Common side effects include nausea, vomiting, diarrhea, and stomach pain. When taken with certain diabetes medications like insulin, there's a higher risk of low blood sugar (hypoglycemia).

    Summary for GLP-1 agonist
    Prescription only

    Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist. It comes in prefilled pens you use to inject the medication under the skin once a week. Wegovy (semaglutide) also comes as tablets that are swallowed once a day. This medication is approved for weight loss in some people. It can help lower the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease. The pens are also approved for certain adults with a liver problem called metabolic dysfunction-associated steatohepatitis (MASH). The medication works best when taken with a lower-calorie diet and regular exercise. Side effects include nausea, diarrhea, and stomach pain.

  • Indications of Trulicity vs. Wegovy

    Indications for
    •Manage Type 2 diabetes in people 10 years and older, along with diet and exercise
    •Lower the risk of heart problems like heart attack, stroke, or death in adults with Type 2 diabetes who have heart disease or heart-related risk factors
    Indications for

    Injectable pens:

    •

    Weight loss and long-term weight management in:

    •People ages 12 years and older who are considered obese
    •Adults considered overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)
    •

    Lowering the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease

    •

    Metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate-to-advanced liver scarring, but not cirrhosis

    Tablets:

    •Weight loss and long-term weight management in adults who are considered obese or overweight with at least one weight-related condition
    •Lowering the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease

  • Pros and Cons of Trulicity vs. Wegovy

    Pros and Const for GLP-1 agonist
    Pros
    •Works well at lowering A1C
    •Comes as a ready-to-use injectable pen
    •Only used once a week
    •Helps with weight loss
    Cons
    •Commonly causes nausea, vomiting, diarrhea, and stomach pain
    •Potential risk for thyroid tumors
    •Can cause problems in the pancreas, kidney, and gallbladder
    •Not recommended for people with stomach problems
    Pros and Const for GLP-1 agonist
    Pros
    •Available as once-weekly injectable pens and as once-daily pills
    •Injectable pens approved for weight loss in children ages 12 years and older considered obese
    Cons
    •Can cause stomach pain, nausea, and diarrhea
    •Can't take with other semaglutide products (Ozempic, Rybelsus) or with other GLP-1 agonists

  • Common Side Effects of Trulicity vs. Wegovy

    Common Side Effects for
    •Nausea (12-21%)
    •Diarrhea (7-13%)
    •Vomiting (6-13%)
    •Stomach pain (7-9%)
    •Low appetite (5-9%)
    •Fatigue (4-6%)
    •Indigestion (3-6%)
    Common Side Effects for
    •Nausea (44%)
    •Diarrhea (30%)
    •Vomiting (24%)
    •Constipation (24%)
    •Stomach pain (20%)
    •Headache (14%)
    •Tiredness (11%)

  • Warnings of Trulicity vs. Wegovy

    Common Side Effects for
    •Thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Low blood sugar when used with certain diabetes medications
    •Severe allergic reactions
    •Kidney damage
    •Severe stomach-related side effects
    •Worsening eye problems in people with diabetic retinopathy
    •Gallbladder problems
    •Breathing fluid into your lungs during anesthesia or deep sedation
    Common Side Effects for
    •Possible risk for thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Gallbladder problems
    •Low blood sugar
    •Kidney damage
    •Allergic reactions
    •Eye problems in people with Type 2 diabetes (diabetic retinopathy)
    •Faster heart rate
    •Possible risk of self-harm
    •Lung problems during general anesthesia or deep sedation

  • Prices with our coupons for Trulicity vs. Wegovy

    Learn more about Trulicity
    Learn more about Wegovy

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