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Compare Adlyxin vs. Ozempic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Adlyxin (lixisenatide) and Ozempic (semaglutide) are both medications used to treat Type 2 diabetes and belong to the glucagon-like peptide-1 (GLP-1) receptor agonist class. However, they have several differences. Adlyxin is injected once daily, while Ozempic is injected once a week, making Ozempic more convenient for some people. Adlyxin has been discontinued in the United States as of January 1, 2023, whereas Ozempic is still available. Ozempic is also approved to lower the risk of heart attack, stroke, and death in people with Type 2 diabetes and heart disease, which is not an indication for Adlyxin. Common side effects of Adlyxin and Ozempic are similar and include nausea, vomiting, and diarrhea. Both medications can cause low blood sugar when taken with other diabetes medications.

  • Adlyxin (lixisenatide)
    Ozempic (semaglutide)
  • Adlyxin (lixisenatide)
    Ozempic (semaglutide)

  • Summary of Adlyxin vs. Ozempic

    Summary for GLP-1 agonist
    Prescription only

    Adlyxin (lixisenatide) is an add-on medication to diet and exercise to improve blood sugar control in people with type 2 diabetes. As of 2023, the medication is no longer available in the United States.

    Summary for GLP-1 agonist
    Prescription only

    Ozempic (semaglutide) is a prescription injection used with diet and exercise to help manage Type 2 diabetes in adults. It's also FDA approved to lower the risk of heart attack, stroke, and heart-related death in those with Type 2 diabetes and heart disease. In addition, it can reduce the risk of worsening kidney problems in people with Type 2 diabetes and chronic kidney disease (CKD). Ozempic (semaglutide) is a GLP-1 agonist that's injected under the skin once a week. Common side effects include nausea, vomiting, and diarrhea.

  • Indications of Adlyxin vs. Ozempic

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes
    •Lower the risk of heart attack, stroke, and heart-related death in adults with Type 2 diabetes and heart disease
    •Lower the risk of worsening kidney problems and heart-related death in adults with Type 2 diabetes and chronic kidney disease (CKD)

  • Pros and Cons of Adlyxin vs. Ozempic

    Pros and Const for GLP-1 agonist
    Pros
    •Lowers A1c (average blood sugar over time) up to 1%.
    •Not as likely to cause very low blood sugar as glyburide or insulin.
    •Adlyxin (lixisenatide) is injected once daily.
    •Adlyxin (lixisenatide) comes as a pre-filled injectable pen that doesn't make you measure out the dose, so you may find this easier to use than other types of injections.
    •Less likely to cause weight gain compared to other diabetic medications.
    •Less risk of nausea compared to other glucagon-like peptide-1 (GLP-1) receptor agonists.
    •There is an insulin and Adlyxin (lixisenatide) combination product available on the market.
    Cons
    •Not good enough by itself if you have really high blood sugars. It needs to be combined with other oral anti-diabetic medicines or insulin.
    •Commonly causes upset stomach.
    •Can make your birth control pills not work as well. Separate them by taking your birth control pill 1 hour before or 11 hours after injecting Adlyxin (lixisenatide).
    •Oral diabetes medications can work just as well and are cheaper.
    •There isn't a generic form of Adlyxin (lixisenatide) available, which means this drug may be pricey.
    •You'll need to remember to take Adlyxin (lixisenatide) 1 hour before the 1st meal of the day.
    •Only available as an injection.
    •Slows stomach emptying which may affect how other medications are absorbed by your body.
    Pros and Const for GLP-1 agonist
    Pros
    •Only given once per week
    •Might help you lose weight
    •Helps lower the risk of heart problems and kidney problems in people with type 2 diabetes
    •Can store open and used pens at room temperature for up to 8 weeks
    Cons
    •Is an injection given under the skin
    •Commonly causes nausea, vomiting, and diarrhea
    •Risk of low blood sugar if taken with certain diabetes medications
    •Can't be used for Type 1 diabetes

  • Common Side Effects of Adlyxin vs. Ozempic

    Common Side Effects for
    •Queasy feeling (25%)
    •Vomiting (10%)
    •Headache (9%)
    •Diarrhea (8%)
    •Dizziness (7%)
    Common Side Effects for
    •Nausea (16-20%)
    •Diarrhea (9%)
    •Vomiting (5-9%)
    •Stomach pain (6-7%)
    •Constipation (3-5%)

  • Warnings of Adlyxin vs. Ozempic

    Common Side Effects for
    •INFLAMMATION OF THE PANCREAS (PANCREATITIS)
    •SEVERE ALLERGIC REACTIONS
    •KIDNEY DAMAGE
    •LOW BLOOD SUGAR (HYPOGLYCEMIA)
    Common Side Effects for
    •Risk of thyroid tumors
    •Inflammation of the pancreas (pancreatitis)
    •Eye problems
    •Low blood sugar (hypoglycemia) when taken with certain diabetes medications
    •Kidney damage
    •Severe stomach problems
    •Severe allergic reactions
    •Gallbladder problems
    •Lung problems during anesthesia or deep sedation

  • Prices with our coupons for Adlyxin vs. Ozempic

    Learn more about Adlyxin
    Learn more about Ozempic

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