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Compare Ozempic vs. Contrave

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Ozempic (semaglutide)
    Contrave (naltrexone / bupropion)
  • Ozempic (semaglutide)
    Contrave (naltrexone / bupropion)

  • Summary of Ozempic vs. Contrave

    Summary for GLP-1 agonist
    Prescription only

    Ozempic (semaglutide) is a prescription injection that's used along with a nutritious diet and exercise to treat Type 2 diabetes in adults. It's also proven to lower the risk of heart attack, stroke, and death due to heart problems in adults with Type 2 diabetes and heart disease. Ozempic (semaglutide) belongs to the drug class known as GLP-1 agonists. The dosing is convenient because it's only injected under the skin once per week. Common side effects of this medication include nausea, vomiting, and diarrhea.

    Summary for Opioid antagonist / Dopamine and norepinephrine reuptake inhibitor
    Prescription only

    Contrave (naltrexone / bupropion) is used along with a lower-calorie diet and exercise routine to help with weight loss for certain adults. This combination medication is a tablet that's taken by mouth. The dosage is slowly raised over the first 3 weeks of treatment until you reach the maintenance dosage of two tablets twice daily. Common side effects include nausea, constipation, and headache. But it can also have more serious risks, such as unusual changes in behavior.

  • Indications of Ozempic vs. Contrave

    Indications for
    •Type 2 diabetes
    •Lower the risk of heart attack, stroke, and death due to heart problems in adults with Type 2 diabetes and heart disease
    Indications for
    •Long-term treatment for weight management in adults with a body mass index (BMI) of 30 kg/m2 or greater; or BMI of 27 kg/m2 or greater and a weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)

  • Pros and Cons of Ozempic vs. Contrave

    Pros and Const for GLP-1 agonist
    Pros
    •Only given once per week
    •Available as prefilled pens for injection
    •Can switch injection days as long as the doses are separated by at least 2 days
    •Can store open and used pens at room temperature for up to 8 weeks
    Cons
    •Must be given as an injection under the skin
    •Commonly causes nausea, vomiting, and diarrhea
    •Risk of low blood sugar if it's taken with certain other diabetes medications (e.g., sulfonylureas, insulins)
    •Can't be used for Type 1 diabetes
    Pros and Const for Opioid antagonist / Dopamine and norepinephrine reuptake inhibitor
    Pros
    •Is a tablet that's taken by mouth
    •Can see results in as early as 4 weeks (when it's taken along with a balanced diet and regular exercise)
    •Combines 2 different medications into a single pill to help with weight
    Cons
    •Must take twice a day (after the dose ramp-up at the beginning)
    •Might raise your risk for unusual behavior and thoughts of self-harm
    •Not available as a lower-cost generic

  • Common Side Effects of Ozempic vs. Contrave

    Common Side Effects for
    •Nausea (16-20%)
    •Diarrhea (9%)
    •Vomiting (5-9%)
    •Stomach pain (6-7%)
    •Constipation (3-5%)
    Common Side Effects for
    •Nausea (33%)
    •Constipation (19%)
    •Headache (18%)
    •Vomiting (11%)
    •Dizziness (10%)
    •Trouble sleeping (9%)
    •Dry mouth (8%)
    •Diarrhea (7%)

  • Warnings of Ozempic vs. Contrave

    Common Side Effects for
    •Thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Eye problems
    •Low blood sugar (hypoglycemia) when taken with certain other diabetes medications
    •Dehydration and kidney problems
    •Severe allergic reactions
    •Gallbladder problems
    Common Side Effects for
    •Suicidal thoughts and behavior
    •Changes in thoughts, behavior, and mood
    •Seizures
    •Don't take Contrave with opioid medications
    •High blood pressure and fast heart rate
    •Liver problems
    •Extreme enthusiasm or excitement (mania)
    •Worsening of glaucoma
    •Potential risk for low blood sugar in certain people with Type 2 diabetes

  • Prices with our coupons for Ozempic vs. Contrave

    Learn more about Ozempic
    Learn more about Contrave

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