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Compare Soliqua 100/33 vs. Ozempic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Soliqua 100/33 (insulin glargine/lixisenatide) and Ozempic (semaglutide) are both injectable medications used to treat Type 2 diabetes. They both contain glucagon-like peptide-1 (GLP-1) agonists, which help lower blood sugar levels. However, Soliqua 100/33 is a combination medication that also contains insulin glargine, a long-acting insulin. Soliqua 100/33 is injected once daily, whereas Ozempic is injected once weekly. Soliqua 100/33 must be taken within an hour before your first meal, while Ozempic can be taken at any time of the day, with or without food. Both medications can cause nausea and diarrhea and may increase your risk for some types of thyroid cancer.

  • Soliqua 100/33
    Ozempic (semaglutide)
  • Soliqua 100/33
    Ozempic (semaglutide)

  • Summary of Soliqua 100/33 vs. Ozempic

    Summary for Insulin / GLP-1 agonist
    Prescription only

    Soliqua 100/33 is a combination medication for diabetes that contains insulin glargine (a long-acting insulin) and lixisenatide (a glucagon-like peptide-1 (GLP-1) receptor agonist). It helps manage blood sugar levels along with diet and exercise in adults with Type 2 diabetes. The medication comes as a prefilled pen and is injected under the skin once a day within 1 hour before you eat your first meal of the day. Soliqua 100/33 commonly causes stomach-related side effects like nausea and diarrhea.

    Summary for GLP-1 agonist
    Prescription only

    Ozempic (semaglutide) is a prescription injection used with diet and exercise to help manage Type 2 diabetes in adults. It's also FDA approved to lower the risk of heart attack, stroke, and heart-related death in those with Type 2 diabetes and heart disease. In addition, it can reduce the risk of worsening kidney problems in people with Type 2 diabetes and chronic kidney disease (CKD). Ozempic (semaglutide) is a GLP-1 agonist that's injected under the skin once a week. Common side effects include nausea, vomiting, and diarrhea.

  • Indications of Soliqua 100/33 vs. Ozempic

    Indications for
    •Type 2 diabetes in adults
    Indications for
    •Type 2 diabetes
    •Lower the risk of heart attack, stroke, and heart-related death in adults with Type 2 diabetes and heart disease
    •Lower the risk of worsening kidney problems and heart-related death in adults with Type 2 diabetes and chronic kidney disease (CKD)

  • Pros and Cons of Soliqua 100/33 vs. Ozempic

    Pros and Const for Insulin / GLP-1 agonist
    Pros
    •Lowers A1C by about 1%
    •Conveniently combines two medications in one injection
    •Injected under the skin once a day
    Cons
    •Risk of low blood sugar, especially if meals are skipped or delayed
    •Commonly causes stomach-related side effects like nausea and diarrhea
    •Must be taken within 1 hour before the first meal of the day
    Pros and Const for GLP-1 agonist
    Pros
    •Only given once per week
    •Might help you lose weight
    •Helps lower the risk of heart problems and kidney problems in people with type 2 diabetes
    •Can store open and used pens at room temperature for up to 8 weeks
    Cons
    •Is an injection given under the skin
    •Commonly causes nausea, vomiting, and diarrhea
    •Risk of low blood sugar if taken with certain diabetes medications
    •Can't be used for Type 1 diabetes

  • Common Side Effects of Soliqua 100/33 vs. Ozempic

    Common Side Effects for
    •Nausea (10%)
    •Low blood sugar (8%)
    •Common cold-like symptoms (7%)
    •Diarrhea (7%)
    •Headache (5%)
    Common Side Effects for
    •Nausea (16-20%)
    •Diarrhea (9%)
    •Vomiting (5-9%)
    •Stomach pain (6-7%)
    •Constipation (3-5%)

  • Warnings of Soliqua 100/33 vs. Ozempic

    Common Side Effects for
    •Severe allergic reactions
    •Inflammation of the pancreas (pancreatitis)
    •Risk of high and low blood sugar levels
    •Dangerously low blood sugar levels (hypoglycemia)
    •Kidney damage
    •Low blood potassium levels
    •Fluid buildup and heart failure with certain diabetes medications
    •Gallbladder problems
    •Aspiration during anesthesia or sedation
    Common Side Effects for
    •Risk of thyroid tumors
    •Inflammation of the pancreas (pancreatitis)
    •Eye problems
    •Low blood sugar (hypoglycemia) when taken with certain diabetes medications
    •Kidney damage
    •Severe stomach problems
    •Severe allergic reactions
    •Gallbladder problems
    •Lung problems during anesthesia or deep sedation

  • Prices with our coupons for Soliqua 100/33 vs. Ozempic

    Learn more about Soliqua 100/33
    Learn more about Ozempic

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