Key takeaways
Soliqua 100/33 (insulin glargine/lixisenatide) and Ozempic (semaglutide) are both injectable medications used to treat Type 2 diabetes. They both contain glucagon-like peptide-1 (GLP-1) agonists, which help lower blood sugar levels. However, Soliqua 100/33 is a combination medication that also contains insulin glargine, a long-acting insulin. Soliqua 100/33 is injected once daily, whereas Ozempic is injected once weekly. Soliqua 100/33 must be taken within an hour before your first meal, while Ozempic can be taken at any time of the day, with or without food. Both medications can cause nausea and diarrhea and may increase your risk for some types of thyroid cancer.
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