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Compare Semglee vs. Ozempic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Semglee (insulin glargine)
    Ozempic (semaglutide)
  • Semglee (insulin glargine)
    Ozempic (semaglutide)

  • Summary of Semglee vs. Ozempic

    Summary for Insulin
    Prescription only

    Semglee (insulin glargine-yfgn or insulin glargine) is a long-acting insulin. It's used to manage blood sugar levels in adults and children with Type 1 diabetes or Type 2 diabetes. Semglee (insulin glargine) is injected under the skin, typically once daily. Your care team will determine your dose of Semglee (insulin glargine) based on different factors, such as your diet and blood sugar levels. Semglee (insulin glargine) comes as a vial and a prefilled insulin pen. Some side effects of this medication include redness and swelling at the injection site, and upper respiratory tract infections. <br> Semglee (insulin glargine) is an interchangeable biosimilar alternative to Lantus (insulin glargine).

    Summary for GLP-1 agonist
    Prescription only

    Ozempic (semaglutide) is a prescription injection that's used along with a nutritious diet and exercise to treat Type 2 diabetes in adults. It's also proven to lower the risk of heart attack, stroke, and death due to heart problems in adults with Type 2 diabetes and heart disease. Ozempic (semaglutide) belongs to the drug class known as GLP-1 agonists. The dosing is convenient because it's only injected under the skin once per week. Common side effects of this medication include nausea, vomiting, and diarrhea.

  • Indications of Semglee vs. Ozempic

    Indications for
    •Type 1 diabetes (T1D)
    •Type 2 diabetes (T2D)
    Indications for
    •Type 2 diabetes
    •Lower the risk of heart attack, stroke, and death due to heart problems in adults with Type 2 diabetes and heart disease

  • Pros and Cons of Semglee vs. Ozempic

    Pros and Const for Insulin
    Pros
    •Can control your blood sugar levels for about 24 hours
    •Can be stored at room temperature for up to 28 days
    •Available in 2 dosage forms: insulin pen and vial
    •Can be substituted for Lantus (insulin glargine)
    Cons
    •Given as an injection
    •Raises risk of dangerously low blood sugar levels
    •Might cause weight gain
    •Can't be mixed with other insulins within the same syringe
    Pros and Const for GLP-1 agonist
    Pros
    •Only given once per week
    •Available as prefilled pens for injection
    •Can switch injection days as long as the doses are separated by at least 2 days
    •Can store open and used pens at room temperature for up to 8 weeks
    Cons
    •Must be given as an injection under the skin
    •Commonly causes nausea, vomiting, and diarrhea
    •Risk of low blood sugar if it's taken with certain other diabetes medications (e.g., sulfonylureas, insulins)
    •Can't be used for Type 1 diabetes

  • Common Side Effects of Semglee vs. Ozempic

    Common Side Effects for

    Type 2 diabetes (T2D)

    •Upper respiratory tract infection (up to 29%)
    •Swelling in the hands or feet (20%)
    •High blood pressure (20%)
    •Flu, sinus infections, or bronchitis (up to 19%)
    •Cataract (15%)
    •Joint pain (14%)
    •Pain in the hands and feet (13%)
    •Back pain (13%)
    •Cough (12%)
    •Urinary tract infection (11%)
    •Diarrhea (11%)
    •Depression (11%)
    •Headache (10%)

    Note: People with T1D typically experienced less side effects than people with T2D, but are at higher risk for hypoglycemia.

    Common Side Effects for
    •Nausea (16-20%)
    •Diarrhea (9%)
    •Vomiting (5-9%)
    •Stomach pain (6-7%)
    •Constipation (3-5%)

  • Warnings of Semglee vs. Ozempic

    Common Side Effects for
    •Risk of serious infections
    •Risk of high and low blood sugar levels
    •Dangerously low blood sugar levels (hypoglycemia)
    •Low blood potassium levels
    •Swelling and heart failure
    •Severe allergic reactions
    Common Side Effects for
    •Thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Eye problems
    •Low blood sugar (hypoglycemia) when taken with certain other diabetes medications
    •Dehydration and kidney problems
    •Severe allergic reactions
    •Gallbladder problems

  • Prices with our coupons for Semglee vs. Ozempic

    Learn more about Semglee
    Learn more about Ozempic

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