Lantus vs. Semglee: 7 Ways These Long-Acting Insulins Compare
Semglee is an interchangeable biosimilar for Lantus. Semglee and Lantus are both approved for Type 1 and 2 diabetes. Compare costs, efficacy, and more at GoodRx.
insulin glargine
Used for Diabetes Type 1, Diabetes Type 2, Gestational Diabetes
Used for Diabetes Type 1, Diabetes Type 2, Gestational Diabetes
Semglee (insulin glargine-yfgn or insulin glargine) is a long-acting insulin. It's used to manage blood sugar levels in adults and children with Type 1 diabetes or Type 2 diabetes. Semglee (insulin glargine) is injected under the skin, typically once daily. Your care team will determine your dose of Semglee (insulin glargine) based on different factors, such as your diet and blood sugar levels. Semglee (insulin glargine) comes as a vial and a prefilled insulin pen. Some side effects of this medication include redness and swelling at the injection site, and upper respiratory tract infections.
Semglee (insulin glargine) is an interchangeable biosimilar alternative to Lantus (insulin glargine).
What is Semglee (insulin glargine)?
What is Semglee (insulin glargine) used for?
How Semglee (insulin glargine) works
Semglee (insulin glargine) is an insulin. Insulin is a natural hormone your body makes to control blood sugar levels. It helps your body absorb and store sugar from the bloodstream after a meal. Insulin also stops your liver from making glucose (sugar). But people with diabetes can't make insulin, don't make enough insulin, or their body doesn't respond to insulin as it should.
Semglee (insulin glargine) is a long-acting, lab-made version of the insulin. It's slowly released into the body and helps your body manage blood sugar levels throughout the day. Semglee (insulin glargine) is used by people who don't make insulin or need more insulin than what their body can produce.
Drug facts
| Common Brands | Semglee |
|---|---|
| Drug Class | Insulin |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
More on Semglee (insulin glargine) essentials
Side effects of Semglee (insulin glargine)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Type 2 diabetes (T2D)
- Upper respiratory tract infection (up to 29%)
- Swelling in the hands or feet (20%)
- High blood pressure (20%)
- Flu, sinus infections, or bronchitis (up to 19%)
- Cataract (15%)
- Joint pain (14%)
- Pain in the hands and feet (13%)
- Back pain (13%)
- Cough (12%)
- Urinary tract infection (11%)
- Diarrhea (11%)
- Depression (11%)
- Headache (10%)
Note: People with T1D typically experienced less side effects than people with T2D, but are at higher risk for hypoglycemia.
Less Common Side Effects
- Dangerously low blood sugar levels (hypoglycemia)
Semglee (insulin glargine) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe hypoglycemia (dangerously low blood sugar): shakiness, nervousness, fast heartbeat, sweating or body chills, confusion, weakness or low energy, extreme hunger; if not treated, it can lead to unconsciousness, seizures, and even death
- Severe allergic reactions: problems breathing, blistering skin rash with a high fever, swelling in your face, mouth, or throat
- Low potassium levels: weakness, muscle cramps or twitches, digestive problems, abnormal heartbeat, kidney problems
The following Semglee (insulin glargine) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Low blood sugar (hypoglycemia)—tremors or shaking, anxiety, sweating, cold or clammy skin, confusion, dizziness, rapid heartbeat
- Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
- Lipodystrophy—hardening or scarring of tissue at injection site
- Pain, redness, or irritation at injection site
- Weight gain
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Manufacturer exclusive discount
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Pros and cons of Semglee (insulin glargine)
Pros
- Can control your blood sugar levels for about 24 hours
- Can be stored at room temperature for up to 28 days
- Available in 2 dosage forms: insulin pen and vial
- Can be substituted for Lantus (insulin glargine)
Cons
- Given as an injection
- Raises risk of dangerously low blood sugar levels
- Might cause weight gain
- Can't be mixed with other insulins within the same syringe
Pharmacist tips for Semglee (insulin glargine)
- Never share Semglee (insulin glargine) pens, syringes, or needles with anyone else. Doing so puts you and others at risk of spreading germs and getting severe and potentially life-threatening infections.
- It's important to check your blood sugar levels regularly to know how well Semglee (insulin glargine) is working. Keep track of your blood sugar readings so that you can share it with your diabetes care team. Your care team might adjust your dose of Semglee (insulin glargine) or other types of insulin you might be using based on trends they see.
- Using Semglee (insulin glargine) can raise your risk of dangerously low blood sugar levels. It's important that you and your caregiver know how to recognize symptoms of low blood sugar level, such as sweating, shakiness, anxiety, and hunger.
- When you're using Semglee (insulin glargine), make sure to always carry fast-acting sugars with you so that you can bring your blood sugar levels up when it drops too low.
Tips on how to use Semglee (insulin glargine)
- Your diabetes care team will train you or your caregiver to inject Semglee (insulin glargine). Read the Instructions for Use for the pre-filled pen or vial and syringe. Contact your care team if you have any questions.
- Before injecting Semglee (insulin glargine), make sure the solution is clear and colorless without any particles. Otherwise, don't inject Semglee (insulin glargine) and ask your prescriber or pharmacist for a replacement.
- Inject Semglee (insulin glargine) under the skin (subcutaneously) of your stomach area, thighs, or back of your upper arms. Be sure to rotate injection sites to prevent hard lumps from forming in your skin. Don't inject Semglee (insulin glargine) into areas of the skin that has pits, is thickened, or is bruised and damaged.
- After giving yourself the Semglee (insulin glargine) injection, throw away any needles and syringe in a sharps container or something made of heavy-duty plastic, such as an empty milk carton or laundry detergent bottle, to lower the risk of needlestick injuries. Don't throw away needles or syringes in your trash can.
Tips on storing Semglee (insulin glargine)
- Unopened Semglee (insulin glargine) vials and pens can be stored in the refrigerator until the expiration date or at room temperature for up to 28 days.
- Opened Semglee (insulin glargine) vials can be stored in the refrigerator or at room temperature for up to 28 days.
- Opened Semglee (insulin glargine) pens should be stored at room temperature for up to 28 days, don't put them in the refrigerator.
Risks and warnings for Semglee (insulin glargine)
Semglee (insulin glargine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk of serious infections
Never share Semglee (insulin glargine) pens, syringes, or needles with anyone else. Doing so puts you and others at risk of getting serious infections, including human immunodeficiency virus (HIV) and hepatitis B (HBV).
Risk of high and low blood sugar levels
Changing your insulin or insulin routine, such as where you inject Semglee (insulin glargine) or switching to a Semglee (insulin glargine) biosimilar, can affect how your body responds to insulin. This can lead to either high or low blood sugar levels. In addition, injecting Semglee (insulin glargine) repeatedly into skin areas that shows signs of lipodystrophy, such as pitting or thickened skin, can also result in high blood sugar levels.
Don't make changes to your Semglee (insulin glargine) dose or routine without first checking in with your diabetes care team. Make sure to avoid injecting into skin areas that show signs of lipodystrophy. If your care team instructs you to make any changes to your insulin routine, they'll also ask you to check your blood sugar levels more often to see how the changes affect your blood sugar levels.
Dangerously low blood sugar levels (hypoglycemia)
- Risk factors: Changes in diet and exercise | Drinking alcohol | Taking other medications for diabetes together with Semglee (insulin glargine) | Liver or kidney problems | Not using Semglee (insulin glargine) as directed
Using Semglee (insulin glargine) alone or together with other medications that lower blood sugar can lead to hypoglycemia, which is dangerously low blood sugar levels. If not treated in time, it can be life-threatening.
Check your blood sugar level regularly to make sure it's within a safe range. If your diabetes care team instructs you to mix different insulins together, read the label of the insulins carefully to make sure you're using the right products. But remember, Semglee (insulin glargine) should never be mixed with other insulins in the same syringe. If you make any changes to your diet or meal patterns, other medications, or how much you exercise, let your care team know because they might need to adjust your dose of Semglee (insulin glargine).
Make sure you're familiar with symptoms of hypoglycemia, such as feeling shaky, being nervous or anxious, sweating or body chills, and excessive hunger. Keep fast-acting sugars, such as glucose tablets, with you at all times so you can treat an episode of hypoglycemia. If your blood sugar levels don't improve even after you take fast-acting sugars, get medical help right away.
Low blood potassium levels
- Risk factors: Taking other medications with Semglee (insulin glargine) that lower potassium
Semglee (insulin glargine) can cause low potassium levels in your blood, which can be dangerous. You're at higher risk if you're already taking medications that can lower potassium levels, such as loop diuretics. Because people with low blood potassium levels typically don't experience any symptoms, your care team might order blood tests to check your potassium levels regularly. And if needed, they'll prescribe you medications to bring your potassium level within a safe range. Get medical help right away if you notice symptoms of low potassium levels such as weakness, muscle cramps or twitches, and constipation.
Swelling and heart failure
- Risk factors: Taking glitazones together with Semglee (insulin glargine) | Heart failure
Taking Semglee (insulin glargine) with glitazones (also known as thiazolidinediones), like Actos (pioglitazone), can cause your body to hold onto fluid. This can be especially dangerous if you have heart failure because additional fluid can worsen your condition and cause symptoms such as difficulty breathing, swelling, and tiredness.
Make sure to tell your diabetes care team if you have heart failure or if you're taking a glitazone before starting Semglee (insulin glargine).
Severe allergic reactions
Rarely, Semglee (insulin glargine) can cause a serious, life-threatening reaction (e.g., anaphylaxis). If you experience swelling in your lips, face, or tongue, rash, or trouble breathing, get medical help right away.
Semglee (insulin glargine) dosage
The average cost for 1 vial of 10ml of 100 units/ml of Semglee (insulin glargine) is $73.14 with a free GoodRx coupon. This is 19.69% off the average retail price of $91.07.
Typical dosage for Semglee (insulin glargine)
Your diabetes care team will work with you to determine your dose of Semglee (insulin glargine). The dose of Semglee (insulin glargine) will be different for each person. It depends on different factors, such as whether you have type 1 or type 2 diabetes and how well your body responds to insulin.
- Type 1 diabetes: Your care team will help you calculate your total daily insulin (TDI) requirement. The typical starting dose is about 30% of your TDI requirement, injected under the skin once daily.
- Type 2 diabetes: Your care team will help you calculate your starting dose based on your body weight. The typical starting dose is 0.2 units/kg (up to 10 units) injected under the skin once daily.
How much does Semglee (insulin glargine) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Semglee (insulin glargine) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Semglee (insulin glargine) will not be safe for you to take.
- Episodes of hypoglycemia (low blood sugar)
What are alternatives to Semglee (insulin glargine)?
There are a number of medications that your doctor can prescribe in place of Semglee (insulin glargine). Compare a few possible alternatives below.
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Semglee (insulin glargine) images
