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Compare Zepbound vs. Ozempic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Zepbound (tirzepatide)
    Ozempic (semaglutide)
  • Zepbound (tirzepatide)
    Ozempic (semaglutide)

  • Summary of Zepbound vs. Ozempic

    Summary for GIP and GLP-1 agonist
    Prescription only

    Zepbound, a brand name for tirzepatide, is an injectable medication that's used along with diet and exercise to help with weight loss. It's approved for certain adults who meet criteria for weight management therapy. Zepbound (tirzepatide) is also approved to treat moderate-to-severe sleep apnea. This medication belongs to the drug class called GIP and GLP-1 agonists. The typical dosage is 1 injection under the skin once per week. Common side effects include nausea, diarrhea, stomach pain, and injection site reactions.

    Summary for GLP-1 agonist
    Prescription only

    Ozempic (semaglutide) is a prescription injection that's used along with a nutritious diet and exercise to treat Type 2 diabetes in adults. It's also proven to lower the risk of heart attack, stroke, and death due to heart problems in adults with Type 2 diabetes and heart disease. Ozempic (semaglutide) belongs to the drug class known as GLP-1 agonists. The dosing is convenient because it's only injected under the skin once per week. Common side effects of this medication include nausea, vomiting, and diarrhea.

  • Indications of Zepbound vs. Ozempic

    Indications for

    In addition to diet and exercise:

    •Weight loss and long-term weight management in adults considered obese or overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes)
    •Moderate-to-severe obstructive sleep apnea (OSA) in adults considered obese
    Indications for
    •Type 2 diabetes
    •Lower the risk of heart attack, stroke, and death due to heart problems in adults with Type 2 diabetes and heart disease

  • Pros and Cons of Zepbound vs. Ozempic

    Pros and Const for GIP and GLP-1 agonist
    Pros
    •Injected once weekly
    •Can take with or without food
    •Different strengths available
    •Can store at room temperature for up to 21 days (3 weeks) if needed
    Cons
    •Can cause bothersome side effects, like nausea, diarrhea, and stomach pain
    •Only available as an injection
    •Has many potential interactions, including with certain diabetes medications, warfarin (Coumadin), and birth control pills
    •Not recommended during pregnancy
    Pros and Const for GLP-1 agonist
    Pros
    •Only given once per week
    •Available as prefilled pens for injection
    •Can switch injection days as long as the doses are separated by at least 2 days
    •Can store open and used pens at room temperature for up to 8 weeks
    Cons
    •Must be given as an injection under the skin
    •Commonly causes nausea, vomiting, and diarrhea
    •Risk of low blood sugar if it's taken with certain other diabetes medications (e.g., sulfonylureas, insulins)
    •Can't be used for Type 1 diabetes

  • Common Side Effects of Zepbound vs. Ozempic

    Common Side Effects for
    •Nausea (25-29%)
    •Diarrhea (19-23%)
    •Constipation (11-17%)
    •Vomiting (8-13%)
    •Stomach pain (9-10%)
    •Indigestion (9-10%)
    Common Side Effects for
    •Nausea (16-20%)
    •Diarrhea (9%)
    •Vomiting (5-9%)
    •Stomach pain (6-7%)
    •Constipation (3-5%)

  • Warnings of Zepbound vs. Ozempic

    Common Side Effects for
    •Risk of thyroid cancer
    •Stomach problems
    •Kidney damage
    •Gallbladder problems
    •Inflammation of the pancreas (pancreatitis)
    •Allergic reactions
    •Low blood sugar (hypoglycemia)
    •Worsened eye problems in people with Type 2 diabetes
    •Suicidal thoughts and behavior
    •Possible risks during general anesthesia
    Common Side Effects for
    •Thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Eye problems
    •Low blood sugar (hypoglycemia) when taken with certain other diabetes medications
    •Dehydration and kidney problems
    •Severe allergic reactions
    •Gallbladder problems

  • Prices with our coupons for Zepbound vs. Ozempic

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    Learn more about Ozempic

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