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Compare Zepbound vs. Contrave

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Zepbound (tirzepatide)
    Contrave (naltrexone / bupropion)
  • Zepbound (tirzepatide)
    Contrave (naltrexone / bupropion)

  • Summary of Zepbound vs. Contrave

    Summary for GIP and GLP-1 agonist
    Prescription only

    Zepbound, a brand name for tirzepatide, is an injectable medication that's used along with diet and exercise to help with weight loss. It's approved for certain adults who meet criteria for weight management therapy. Zepbound (tirzepatide) is also approved to treat moderate-to-severe sleep apnea. This medication belongs to the drug class called GIP and GLP-1 agonists. The typical dosage is 1 injection under the skin once per week. Common side effects include nausea, diarrhea, stomach pain, and injection site reactions.

    Summary for Opioid antagonist / Dopamine and norepinephrine reuptake inhibitor
    Prescription only

    Contrave (naltrexone / bupropion) is used along with a lower-calorie diet and exercise routine to help with weight loss for certain adults. This combination medication is a tablet that's taken by mouth. The dosage is slowly raised over the first 3 weeks of treatment until you reach the maintenance dosage of two tablets twice daily. Common side effects include nausea, constipation, and headache. But it can also have more serious risks, such as unusual changes in behavior.

  • Indications of Zepbound vs. Contrave

    Indications for

    In addition to diet and exercise:

    •Weight loss and long-term weight management in adults considered obese or overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes)
    •Moderate-to-severe obstructive sleep apnea (OSA) in adults considered obese
    Indications for
    •Long-term treatment for weight management in adults with a body mass index (BMI) of 30 kg/m2 or greater; or BMI of 27 kg/m2 or greater and a weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)

  • Pros and Cons of Zepbound vs. Contrave

    Pros and Const for GIP and GLP-1 agonist
    Pros
    •Injected once weekly
    •Can take with or without food
    •Different strengths available
    •Can store at room temperature for up to 21 days (3 weeks) if needed
    Cons
    •Can cause bothersome side effects, like nausea, diarrhea, and stomach pain
    •Only available as an injection
    •Has many potential interactions, including with certain diabetes medications, warfarin (Coumadin), and birth control pills
    •Not recommended during pregnancy
    Pros and Const for Opioid antagonist / Dopamine and norepinephrine reuptake inhibitor
    Pros
    •Is a tablet that's taken by mouth
    •Can see results in as early as 4 weeks (when it's taken along with a balanced diet and regular exercise)
    •Combines 2 different medications into a single pill to help with weight
    Cons
    •Must take twice a day (after the dose ramp-up at the beginning)
    •Might raise your risk for unusual behavior and thoughts of self-harm
    •Not available as a lower-cost generic

  • Common Side Effects of Zepbound vs. Contrave

    Common Side Effects for
    •Nausea (25-29%)
    •Diarrhea (19-23%)
    •Constipation (11-17%)
    •Vomiting (8-13%)
    •Stomach pain (9-10%)
    •Indigestion (9-10%)
    Common Side Effects for
    •Nausea (33%)
    •Constipation (19%)
    •Headache (18%)
    •Vomiting (11%)
    •Dizziness (10%)
    •Trouble sleeping (9%)
    •Dry mouth (8%)
    •Diarrhea (7%)

  • Warnings of Zepbound vs. Contrave

    Common Side Effects for
    •Risk of thyroid cancer
    •Stomach problems
    •Kidney damage
    •Gallbladder problems
    •Inflammation of the pancreas (pancreatitis)
    •Allergic reactions
    •Low blood sugar (hypoglycemia)
    •Worsened eye problems in people with Type 2 diabetes
    •Suicidal thoughts and behavior
    •Possible risks during general anesthesia
    Common Side Effects for
    •Suicidal thoughts and behavior
    •Changes in thoughts, behavior, and mood
    •Seizures
    •Don't take Contrave with opioid medications
    •High blood pressure and fast heart rate
    •Liver problems
    •Extreme enthusiasm or excitement (mania)
    •Worsening of glaucoma
    •Potential risk for low blood sugar in certain people with Type 2 diabetes

  • Prices with our coupons for Zepbound vs. Contrave

    Learn more about Zepbound
    Learn more about Contrave

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