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Compare Zepbound vs. Wegovy

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Zepbound (tirzepatide)
Wegovy (semaglutide)
Zepbound (tirzepatide)
Wegovy (semaglutide)

Summary of Zepbound vs. Wegovy

Summary for GIP and GLP-1 agonist
Prescription only

Zepbound, a brand name for tirzepatide, is an injectable medication that's used along with diet and exercise to help with weight loss. It's approved for certain adults who meet criteria for weight management therapy. Zepbound (tirzepatide) is also approved to treat moderate-to-severe sleep apnea. This medication belongs to the drug class called GIP and GLP-1 agonists. The typical dosage is 1 injection under the skin once per week. Common side effects include nausea, diarrhea, stomach pain, and injection site reactions.

Summary for GLP-1 agonist
Prescription only

Wegovy (semaglutide) is used in addition to a lower-calorie diet and exercise plan to help with weight loss in certain adults and children 12 years of age and older. It's also proven to lower the risk for heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease. This medication belongs to the drug class called glucagon-like peptide-1 (GLP-1) receptor agonists. The dosing schedule for Wegovy (semaglutide) is once a week, and the medication is injected under your skin. Common side effects include nausea, diarrhea, and stomach pain.

Indications of Zepbound vs. Wegovy

Indications for

In addition to diet and exercise:

•Weight loss and long-term weight management in adults considered obese or overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes)
•Moderate-to-severe obstructive sleep apnea (OSA) in adults considered obese
Indications for
•Long-term treatment for weight management in:
•Adults with a body mass index (BMI) of 30 kg/m2 or greater; or BMI of 27 kg/m2 or greater and a weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)
•Children 12 years of age and older with a baseline BMI at the 95th percentile or greater
•Lowering the risk of heart attack, stroke, and death due to heart problems in adults with heart disease and a larger body size

Pros and Cons of Zepbound vs. Wegovy

Pros and Const for GIP and GLP-1 agonist
Pros
•Injected once weekly
•Can take with or without food
•Different strengths available
•Can store at room temperature for up to 21 days (3 weeks) if needed
Cons
•Can cause bothersome side effects, like nausea, diarrhea, and stomach pain
•Only available as an injection
•Has many potential interactions, including with certain diabetes medications, warfarin (Coumadin), and birth control pills
•Not recommended during pregnancy
Pros and Const for GLP-1 agonist
Pros
•Can help you lose weight when it's used along with a nutritious diet and regular exercise
•Approved for use for weight loss in certain children aged 12 years and older (BMI at or above the 95th percentile)
•Injected once a week
Cons
•Must inject under the skin
•Can cause stomach pain, nausea, and diarrhea
•Can't take with other semaglutide products (Ozempic, Rybelsus) or with other GLP-1 agonists

Common Side Effects of Zepbound vs. Wegovy

Common Side Effects for
•Nausea (25-29%)
•Diarrhea (19-23%)
•Constipation (11-17%)
•Vomiting (8-13%)
•Stomach pain (9-10%)
•Indigestion (9-10%)
Common Side Effects for
•Nausea (44%)
•Diarrhea (30%)
•Vomiting (24%)
•Constipation (24%)
•Stomach pain (20%)
•Headache (14%)
•Tiredness (11%)

Warnings of Zepbound vs. Wegovy

Common Side Effects for
•Risk of thyroid cancer
•Stomach problems
•Kidney damage
•Gallbladder problems
•Inflammation of the pancreas (pancreatitis)
•Allergic reactions
•Low blood sugar (hypoglycemia)
•Worsened eye problems in people with Type 2 diabetes
•Suicidal thoughts and behavior
•Possible risks during general anesthesia
Common Side Effects for
•Possible risk for thyroid cancer
•Inflammation of the pancreas (pancreatitis)
•Gallbladder problems
•Low blood sugar
•Kidney damage
•Allergic reactions
•Eye problems in people with Type 2 diabetes (diabetic retinopathy)
•Faster heart rate
•Possible risk for self-harm

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