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Compare Zepbound vs. Saxenda

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Zepbound (tirzepatide)
    Saxenda (liraglutide)
  • Zepbound (tirzepatide)
    Saxenda (liraglutide)

  • Summary of Zepbound vs. Saxenda

    Summary for GIP and GLP-1 agonist
    Prescription only

    Zepbound, a brand name for tirzepatide, is an injectable medication that's used along with diet and exercise to help with weight loss. It's approved for certain adults who meet criteria for weight management therapy. Zepbound (tirzepatide) is also approved to treat moderate-to-severe sleep apnea. This medication belongs to the drug class called GIP and GLP-1 agonists. The typical dosage is 1 injection under the skin once per week. Common side effects include nausea, diarrhea, stomach pain, and injection site reactions.

    Summary for GLP-1 agonist
    Prescription only

    Saxenda (liraglutide) is used along with a balanced diet and exercise to help with weight loss in certain adults and children. This prescription weight loss medication is a glucagon-like peptide-1 (GLP-1) receptor agonist. It works by slowing down your gut and making you feel less hungry. Saxenda (liraglutide) is a prefilled pen of medication that's injected once daily under the skin on the stomach or thighs. You can inject Saxenda (liraglutide) at home by yourself after your healthcare professional (HCP) trains you on how to prepare and use it. Some common side effects include nausea, vomiting, and diarrhea.

  • Indications of Zepbound vs. Saxenda

    Indications for

    In addition to diet and exercise:

    •Weight loss and long-term weight management in adults considered obese or overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes)
    •Moderate-to-severe obstructive sleep apnea (OSA) in adults considered obese
    Indications for
    •To help with weight management along with a lower-calorie diet and exercise in:
    •Adults with a body mass index (BMI) greater than 30 kg/m2, or greater than 27 kg/m2 with a weight-related health problem (e.g., high blood pressure, Type 2 diabetes, high cholesterol)
    •Children 12 years of age and older who weigh over 132 lbs and have a high BMI

  • Pros and Cons of Zepbound vs. Saxenda

    Pros and Const for GIP and GLP-1 agonist
    Pros
    •Injected once weekly
    •Can take with or without food
    •Different strengths available
    •Can store at room temperature for up to 21 days (3 weeks) if needed
    Cons
    •Can cause bothersome side effects, like nausea, diarrhea, and stomach pain
    •Only available as an injection
    •Has many potential interactions, including with certain diabetes medications, warfarin (Coumadin), and birth control pills
    •Not recommended during pregnancy
    Pros and Const for GLP-1 agonist
    Pros
    •Can help you lose weight in addition to balanced nutrition and exercise
    •Can take with or without food
    •Safe to use for children 12 years of age and older (with certain BMI)
    Cons
    •Must be given as once-daily injections under the skin
    •Can cause stomach upset
    •Not safe for use for people with personal or family history of thyroid cancer

  • Common Side Effects of Zepbound vs. Saxenda

    Common Side Effects for
    •Nausea (25-29%)
    •Diarrhea (19-23%)
    •Constipation (11-17%)
    •Vomiting (8-13%)
    •Stomach pain (9-10%)
    •Indigestion (9-10%)
    Common Side Effects for

    Adults:

    •Nausea (39%)
    •Diarrhea (21%)
    •Constipation (19%)
    •Vomiting (16%)
    •Redness, itching, and other injection site reactions (14%)
    •Headache (14%)
    •Low blood sugar levels in people with Type 2 diabetes (13%)
    •Indigestion (10%)

    Children 12 years of age and older:

    •Nausea (42%)
    •Vomiting (34%)
    •Diarrhea (22%)
    •Low blood sugar levels (15%)
    •Dizziness (10%)

  • Warnings of Zepbound vs. Saxenda

    Common Side Effects for
    •Risk of thyroid cancer
    •Stomach problems
    •Kidney damage
    •Gallbladder problems
    •Inflammation of the pancreas (pancreatitis)
    •Allergic reactions
    •Low blood sugar (hypoglycemia)
    •Worsened eye problems in people with Type 2 diabetes
    •Suicidal thoughts and behavior
    •Possible risks during general anesthesia
    Common Side Effects for
    •Possible risk for thyroid cancer
    •Inflamed pancreas
    •Gallbladder problems
    •Low blood sugar
    •Faster heart rate
    •Kidney problems
    •Serious allergic reactions
    •Possible risk for self-harm

  • Prices with our coupons for Zepbound vs. Saxenda

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    Learn more about Saxenda

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