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Compare Phentermine vs. Zepbound

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Phentermine (Adipex-P)
    Zepbound (tirzepatide)
  • Phentermine (Adipex-P)
    Zepbound (tirzepatide)

  • Summary of Phentermine vs. Zepbound

    Summary for Sympathomimetic
    Prescription only

    Phentermine (Adipex-P) is an appetite suppressant. It's a prescription weight loss pill for people ages 17 years and older. This medication works best when it's part of a treatment plan that involves healthy diet and regular exercise. Phentermine (Adipex-P) is taken by mouth once daily, typically in the morning. Some of the more common side effects of this medication include dry mouth, trouble sleeping, and headache.

    Summary for GIP and GLP-1 agonist
    Prescription only

    Zepbound, a brand name for tirzepatide, is an injectable medication that's used along with diet and exercise to help with weight loss. It's approved for certain adults who meet criteria for weight management therapy. Zepbound (tirzepatide) is also approved to treat moderate-to-severe sleep apnea. This medication belongs to the drug class called GIP and GLP-1 agonists. The typical dosage is 1 injection under the skin once per week. Common side effects include nausea, diarrhea, stomach pain, and injection site reactions.

  • Indications of Phentermine vs. Zepbound

    Indications for

    Short-term treatment for weight management in adults with a body mass index (BMI) of:

    •30 kg/m2 or greater; or
    •27 kg/m2 or greater, and with at least one other weight-related condition (e.g., high blood pressure, high blood sugar, high cholesterol)
    Indications for

    In addition to diet and exercise:

    •Weight loss and long-term weight management in adults considered obese or overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes)
    •Moderate-to-severe obstructive sleep apnea (OSA) in adults considered obese

  • Pros and Cons of Phentermine vs. Zepbound

    Pros and Const for Sympathomimetic
    Pros
    •Can help you lose 5% to 10% of body weight
    •Usually taken by mouth once per day
    •Available as a lower-cost generic
    •Comes as tablets, capsules, and orally disintegrating tablets
    Cons
    •Most insurance companies don't cover the cost of phentermine (Adipex-P).
    •Has a risk of misuse and dependence since it's a stimulant medication that's similar to amphetamines
    •Might not be a good choice for people with high blood pressure
    •Should be avoided in children 16 years of age and younger, pregnant and breastfeeding women, and people with serious heart problems
    Pros and Const for GIP and GLP-1 agonist
    Pros
    •Injected once weekly
    •Can take with or without food
    •Different strengths available
    •Can store at room temperature for up to 21 days (3 weeks) if needed
    Cons
    •Can cause bothersome side effects, like nausea, diarrhea, and stomach pain
    •Only available as an injection
    •Has many potential interactions, including with certain diabetes medications, warfarin (Coumadin), and birth control pills
    •Not recommended during pregnancy

  • Common Side Effects of Phentermine vs. Zepbound

    Common Side Effects for
    •Dry mouth
    •Headache
    •Tremor
    •Constipation
    •Diarrhea
    •High blood pressure
    •Fast heart rate
    •Difficulty sleeping
    Common Side Effects for
    •Nausea (25-29%)
    •Diarrhea (19-23%)
    •Constipation (11-17%)
    •Vomiting (8-13%)
    •Stomach pain (9-10%)
    •Indigestion (9-10%)

  • Warnings of Phentermine vs. Zepbound

    Common Side Effects for
    •Not safe to combined with other weight loss medications
    •Phentermine not working well
    •Risk of misuse and dependence
    •Trouble concentrating or problem with coordination
    •Heart and lung problems
    •Risk of high blood pressure
    •Risk of low blood sugar in people with diabetes
    Common Side Effects for
    •Risk of thyroid cancer
    •Stomach problems
    •Kidney damage
    •Gallbladder problems
    •Inflammation of the pancreas (pancreatitis)
    •Allergic reactions
    •Low blood sugar (hypoglycemia)
    •Worsened eye problems in people with Type 2 diabetes
    •Suicidal thoughts and behavior
    •Possible risks during general anesthesia

  • Prices with our coupons for Phentermine vs. Zepbound

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