Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Liraglutide (Saxenda) and phentermine (Adipex-P) are both medications used to help with weight loss, but they belong to different medication classes and work in different ways. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that helps control appetite by slowing down your gut, making you feel less hungry. It is injected under the skin once daily. Phentermine, on the other hand, is a sympathomimetic stimulant that suppresses appetite and is taken orally, usually once a day in the morning. While both medications are used for weight management, liraglutide is approved for use in adults and children over 12 with a high body mass index (BMI). Phentermine is only approved for short-term use in people who are 17 years of age and older. Liraglutide is not a controlled substance, but phentermine is a Schedule IV controlled substance due to its potential for misuse and dependence. Common side effects of liraglutide include nausea, vomiting, and diarrhea, while phentermine can cause dry mouth and trouble sleeping. Additionally, you should avoid combining either medication with other weight loss medications.
Saxenda (liraglutide)
Phentermine (Adipex-P)
Saxenda (liraglutide)
Phentermine (Adipex-P)
Summary of Saxenda vs. Phentermine
Summary for GLP-1 agonist
Prescription only
Saxenda (liraglutide) is used along with a balanced diet and exercise to help with weight loss in certain adults and children. This prescription weight loss medication is a glucagon-like peptide-1 (GLP-1) receptor agonist. It works by slowing down your gut and making you feel less hungry. Saxenda (liraglutide) is a prefilled pen of medication that's injected once daily under the skin on the stomach or thighs. You can inject Saxenda (liraglutide) at home by yourself after your healthcare professional (HCP) trains you on how to prepare and use it. Some common side effects include nausea, vomiting, and diarrhea.
Summary for Sympathomimetic
Prescription only
Phentermine (Adipex-P) is an appetite suppressant. It's a prescription weight loss pill for people ages 17 years and older. This medication works best when it's part of a treatment plan that involves healthy diet and regular exercise. Phentermine (Adipex-P) is taken by mouth once daily, typically in the morning. Some of the more common side effects of this medication include dry mouth, trouble sleeping, and headache.
Indications of Saxenda vs. Phentermine
Indications for
•To help with weight management along with a lower-calorie diet and exercise in: