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Foundayo vs. Saxenda

Foundayo (orforglipron) is an oral glucagon-like peptide-1 (GLP-1) receptor agonist. It's approved for weight loss in certain adults. This medication is meant to be used together with a reduced-calorie diet and exercise. Foundayo (orforglipron) comes as tablets and is taken by mouth once a day with or without food. The dose is slowly raised over several weeks. Common side effects include nausea, constipation, and diarrhea.

• Weight loss and long-term weight management in adults who are considered obese or overweight with at least one weight-related condition

• Nausea (26-35%)
• Constipation (20-27%)
• Diarrhea (21-25%)
• Vomiting (13-24%)
• Indigestion (12-16%)
• Stomach pain (13-14%)
• Headache (8-9%)
• Bloating (7-9%)
• Feeling tired (6-9%)
• Belching (6-8%)
• Gastroesophageal reflux disease (GERD; 6-7%)
• Having a lot of gas (5-6%)
• Hair loss (4-5%)

• Possible risk of thyroid cancer
• Severe stomach side effects
• Kidney damage
• Inflammation of the pancreas (pancreatitis)
• Gallbladder problems
• Low blood sugar
• Allergic reactions
• Eye problems in people with Type 2 diabetes (diabetic retinopathy)
• Lung problems during general anesthesia or deep sedation

Saxenda (generic name liraglutide) is a once-daily injection given under the skin that's used for weight loss. It's approved for certain adults and children ages 12 years and up. And it works best when used along with a balanced diet and exercise. This prescription weight loss medication is a glucagon-like peptide-1 (GLP-1) agonist. It works by slowing down your gut and making you feel less hungry. Saxenda (liraglutide) comes as a prefilled pen you use to inject your dose. Some common side effects include nausea, vomiting, and diarrhea.

• Weight loss and long-term weight management in:
  • People ages 12 years and older with a body weight greater than 132 lbs and obesity
  • Adults who are considered overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)

Adults:

• Nausea (39%)
• Diarrhea (21%)
• Constipation (19%)
• Vomiting (16%)
• Injection site reaction (e.g., redness, itching, rash; 14%)
• Headache (14%)
• Low blood sugar in people with Type 2 diabetes (13%)
• Indigestion (10%)

Children 12 years and up:

• Nausea (42%)
• Vomiting (34%)
• Diarrhea (22%)
• Low blood sugar (15%)
• Stomach inflammation (13%)
• Dizziness (10%)

• Possible risk for thyroid cancer
• Inflammation of the pancreas (pancreatitis)
• Gallbladder problems
• Low blood sugar
• Faster heart rate
• Severe stomach side effects
• Kidney problems due to dehydration
• Allergic reactions
• Lung problems during anesthesia or deep sedation