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Compare Wegovy vs. Mounjaro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Semaglutide (Wegovy) and tirzepatide (Mounjaro) are both injectable medications used under the skin once a week. Semaglutide is a glucagon-like peptide-1 (GLP-1) agonist, while tirzepatide is a dual GIP and GLP-1 agonist. Wegovy is FDA-approved for long-term weight management in adults and children aged 12 and older living with overweight or obesity, and it also helps lower the risk of heart problems in adults with heart disease and a larger body size. Mounjaro, on the other hand, is FDA-approved for improving blood sugar control in adults with Type 2 diabetes. While both medications can cause side effects like nausea and diarrhea, Wegovy is more likely to cause stomach pain, while Mounjaro can lead to low appetite. Both Wegovy and Mounjaro are available only as branded medications. Both medications have a potential risk for thyroid cancer, so they should not be used by those with a personal or family history of certain thyroid cancers.

  • Wegovy (semaglutide)
    Mounjaro (tirzepatide)
  • Wegovy (semaglutide)
    Mounjaro (tirzepatide)

  • Summary of Wegovy vs. Mounjaro

    Summary for GLP-1 agonist
    Prescription only

    Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist. It comes in prefilled pens you use to inject the medication under the skin once a week. Wegovy (semaglutide) also comes as tablets that are swallowed once a day. This medication is approved for weight loss in some people. It can help lower the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease. The pens are also approved for certain adults with a liver problem called metabolic dysfunction-associated steatohepatitis (MASH). The medication works best when taken with a lower-calorie diet and regular exercise. Side effects include nausea, diarrhea, and stomach pain.

    Summary for GIP and GLP-1 agonist
    Prescription only

    Mounjaro (tirzepatide) is a prescription injection used to improve blood sugar control in people 10 years and older with Type 2 diabetes. It works best when you also follow a nutritious diet and exercise regularly. Mounjaro (tirzepatide) belongs to the drug class called GIP and GLP-1 agonists. The dosage is convenient because it's injected under the skin once a week. Some common side effects of Mounjaro (tirzepatide) include nausea and diarrhea. It can also lower your appetite, which might lead to some weight loss.

  • Indications of Wegovy vs. Mounjaro

    Indications for

    Injectable pens:

    •

    Weight loss and long-term weight management in:

    •People ages 12 years and older who are considered obese
    •Adults considered overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)
    •

    Lowering the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease

    •

    Metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate-to-advanced liver scarring, but not cirrhosis

    Tablets:

    •Weight loss and long-term weight management in adults who are considered obese or overweight with at least one weight-related condition
    •Lowering the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease
    Indications for
    •Type 2 diabetes in adults and children 10 years of age and older

  • Pros and Cons of Wegovy vs. Mounjaro

    Pros and Const for GLP-1 agonist
    Pros
    •Available as once-weekly injectable pens and as once-daily pills
    •Injectable pens approved for weight loss in children ages 12 years and older considered obese
    Cons
    •Can cause stomach pain, nausea, and diarrhea
    •Can't take with other semaglutide products (Ozempic, Rybelsus) or with other GLP-1 agonists
    Pros and Const for GIP and GLP-1 agonist
    Pros
    •Given once weekly
    •Can lower A1C by an average of up to 2.3% in about 9 months
    •Comes in vials and ready-to-use injectable pens
    •Can use if you have liver or kidney problems
    Cons
    •Only available as an injection given under the skin
    •Can cause unpleasant side effects like nausea, vomiting, and diarrhea
    •Takes time to reach a dose that works well
    •Might not be safe during pregnancy

  • Common Side Effects of Wegovy vs. Mounjaro

    Common Side Effects for
    •Nausea (44%)
    •Diarrhea (30%)
    •Vomiting (24%)
    •Constipation (24%)
    •Stomach pain (20%)
    •Headache (14%)
    •Tiredness (11%)
    Common Side Effects for
    •Nausea (12-18%)
    •Diarrhea (12-17%)
    •Low appetite (5-11%)
    •Vomiting (5-9%)
    •Indigestion (5-8%)
    •Constipation (6-7%)
    •Stomach pain (5-6%)

  • Warnings of Wegovy vs. Mounjaro

    Common Side Effects for
    •Possible risk for thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Gallbladder problems
    •Low blood sugar
    •Kidney damage
    •Allergic reactions
    •Eye problems in people with Type 2 diabetes (diabetic retinopathy)
    •Faster heart rate
    •Possible risk of self-harm
    •Lung problems during general anesthesia or deep sedation
    Common Side Effects for
    •Risk of thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Low blood sugar (hypoglycemia) when used with other diabetes medications
    •Allergic reactions
    •Stomach side effects
    •Kidney damage due to dehydration
    •Eye problems in people with diabetic retinopathy
    •Gallbladder problems
    •Lung problems during general anesthesia or deep sedation

  • Prices with our coupons for Wegovy vs. Mounjaro

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