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Compare Plenity vs. Wegovy

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Plenity (cellulose/citric acid) and Wegovy (semaglutide) are both used for weight management, but they have some important differences. Plenity is a medical device in pill form, while Wegovy is a glucagon-like peptide-1 (GLP-1) agonist medication. Plenity is taken orally with water before lunch and dinner, whereas Wegovy is injected under the skin once a week. Plenity is made from natural ingredients and works by expanding in your stomach to make you feel full, while Wegovy slows down your gut and controls your appetite. Plenity is only approved for adults, but Wegovy can be used by adults and children 12 years and older. Common side effects of Plenity include diarrhea and bloating, while Wegovy may cause nausea and stomach pain. Plenity might affect how other medications are absorbed, so you should discuss this with your healthcare provider. Wegovy may increasde the risk for thyroid cancer and pancreatitis, so it's important to talk to your prescriber about your medical history before starting it.

  • Plenity
    Wegovy (semaglutide)
  • Plenity
    Wegovy (semaglutide)

  • Summary of Plenity vs. Wegovy

    Summary for Medical device
    Prescription only

    Plenity is an FDA-cleared medical device in pill form that's used for weight loss. It's taken by mouth along with a healthy diet and regular exercise through a weight management program that's supervised by a healthcare provider. Plenity is made up of natural ingredients (cellulose and citric acid). Since it works directly in your digestive tract, Plenity can help you feel full and eat less. But it might cause side effects like diarrhea, constipation, and bloating. Plenity is not a medication, and it might not be safe for people with stomach issues.

    Summary for GLP-1 agonist
    Prescription only

    Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist. It comes in prefilled pens you use to inject the medication under the skin once a week. Wegovy (semaglutide) also comes as tablets that are swallowed once a day. This medication is approved for weight loss in some people. It can help lower the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease. The pens are also approved for certain adults with a liver problem called metabolic dysfunction-associated steatohepatitis (MASH). The medication works best when taken with a lower-calorie diet and regular exercise. Side effects include nausea, diarrhea, and stomach pain.

  • Indications of Plenity vs. Wegovy

    Indications for
    •Weight loss, used in addition to a healthy diet and regular exercise
    Indications for

    Injectable pens:

    •

    Weight loss and long-term weight management in:

    •People ages 12 years and older who are considered obese
    •Adults considered overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)
    •

    Lowering the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease

    •

    Metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate-to-advanced liver scarring, but not cirrhosis

    Tablets:

    •Weight loss and long-term weight management in adults who are considered obese or overweight with at least one weight-related condition
    •Lowering the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease

  • Pros and Cons of Plenity vs. Wegovy

    Pros and Const for Medical device
    Pros
    •Generally few side effects
    •Is not a medication
    Cons
    •Need to take three pills for each dose
    •Might need to avoid or use with caution if you have stomach issues or trouble swallowing
    Pros and Const for GLP-1 agonist
    Pros
    •Available as once-weekly injectable pens and as once-daily pills
    •Injectable pens approved for weight loss in children ages 12 years and older considered obese
    Cons
    •Can cause stomach pain, nausea, and diarrhea
    •Can't take with other semaglutide products (Ozempic, Rybelsus) or with other GLP-1 agonists

  • Common Side Effects of Plenity vs. Wegovy

    Common Side Effects for
    •Diarrhea (13%)
    •Bloating or swelling in the stomach area (12%)
    •Common cold symptoms (12%)
    •Passing gas (9%)
    •Constipation or not having bowel movements often (5-9%)
    •Headache (7%)
    •Stomach pain (5%)
    •Nausea (5%)

    In clinical studies, there were no overall differences in the rate of side effects between those using Plenity and those using placebo.

    Common Side Effects for
    •Nausea (44%)
    •Diarrhea (30%)
    •Vomiting (24%)
    •Constipation (24%)
    •Stomach pain (20%)
    •Headache (14%)
    •Tiredness (11%)

  • Warnings of Plenity vs. Wegovy

    Common Side Effects for
    •Trouble swallowing Plenity
    •Caution in people with stomach issues
    •Not a food substitute
    Common Side Effects for
    •Possible risk for thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Gallbladder problems
    •Low blood sugar
    •Kidney damage
    •Allergic reactions
    •Eye problems in people with Type 2 diabetes (diabetic retinopathy)
    •Faster heart rate
    •Possible risk of self-harm
    •Lung problems during general anesthesia or deep sedation

  • Prices with our coupons for Plenity vs. Wegovy

    Learn more about Plenity
    Learn more about Wegovy

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