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Compare Rybelsus vs. Wegovy

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Rybelsus (semaglutide)
    Wegovy (semaglutide)
  • Rybelsus (semaglutide)
    Wegovy (semaglutide)

  • Summary of Rybelsus vs. Wegovy

    Summary for GLP-1 agonist
    Prescription only

    Rybelsus (semaglutide) is a brand name glucagon-like peptide-1 (GLP-1) agonist that helps lower blood sugar in adults with Type 2 diabetes. Unlike other medications in this class, it's the first one available as a tablet you take by mouth. The pill is typically taken once a day, at least 30 minutes before you eat, drink, or take any other medications by mouth. It’s used along with diet and exercise, and might also help with weight loss. Common side effects include nausea, stomach pain, and diarrhea.

    Summary for GLP-1 agonist
    Prescription only

    Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist that's injected under the skin. It's used together with a lower-calorie diet and regular exercise. Wegovy (semaglutide) is approved to help with weight loss in certain adults and children 12 years of age and older. It also helps lower the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease. The dosing schedule for the injections is once a week. Common side effects include nausea, diarrhea, and stomach pain.

  • Indications of Rybelsus vs. Wegovy

    Indications for
    •Type 2 diabetes
    Indications for
    •

    Weight loss and long-term weight management in:

    •People ages 12 years and older who are considered obese
    •Adults considered overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)
    •

    Lowering the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease

  • Pros and Cons of Rybelsus vs. Wegovy

    Pros and Const for GLP-1 agonist
    Pros
    •Only needs to be taken once per day
    •First GLP-1 agonist in pill form
    •Helps lower blood sugar and might also support weight loss
    Cons
    •Must be taken on an empty stomach
    •Stomach side effects like nausea, diarrhea, and stomach pain are common
    •Can't be used for Type 1 diabetes
    Pros and Const for GLP-1 agonist
    Pros
    •Can help you lose weight when it's used along with a nutritious diet and regular exercise
    •Approved for helping with weight loss for children ages 12 years and older considered obese
    •Injected once a week
    Cons
    •Must inject under the skin
    •Can cause stomach pain, nausea, and diarrhea
    •Can't take with other semaglutide products (Ozempic, Rybelsus) or with other GLP-1 agonists

  • Common Side Effects of Rybelsus vs. Wegovy

    Common Side Effects for
    •Nausea (11-20%)
    •Stomach pain (10-11%)
    •Diarrhea (9-10%)
    •Lower appetite (6-9%)
    •Vomiting (6-8%)
    •Constipation (5-6%)
    Common Side Effects for
    •Nausea (44%)
    •Diarrhea (30%)
    •Vomiting (24%)
    •Constipation (24%)
    •Stomach pain (20%)
    •Headache (14%)
    •Tiredness (11%)

  • Warnings of Rybelsus vs. Wegovy

    Common Side Effects for
    •Risk of thyroid tumors
    •Inflammation of the pancreas (pancreatitis)
    •Eye problems
    •Low blood sugar (hypoglycemia) when taken with certain diabetes medications
    •Kidney damage
    •Severe stomach side effects
    •Severe allergic reactions
    •Gallbladder problems
    •Lung problems during anesthesia or deep sedation
    Common Side Effects for
    •Possible risk for thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Gallbladder problems
    •Low blood sugar
    •Kidney damage
    •Allergic reactions
    •Eye problems in people with Type 2 diabetes (diabetic retinopathy)
    •Faster heart rate
    •Possible risk of self-harm
    •Lung problems during general anesthesia or deep sedation

  • Prices with our coupons for Rybelsus vs. Wegovy

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