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Rybelsus vs. Saxenda

Rybelsus (semaglutide) is a brand-name GLP-1 agonist that helps lower blood sugar in adults with Type 2 diabetes. It's also FDA approved to help reduce the risk of heart attack, stroke, and heart-related death in people with Type 2 diabetes who are at risk for these events. You take it as a pill once a day, at least 30 minutes before eating, drinking, or taking other medicatons by mouth. It’s used along with diet and exercise, and might also help with weight loss. Common side effects include nausea, stomach pain, and diarrhea.

• Type 2 diabetes
• Lower the risk of heart attack, stroke, and heart-related death in adults with Type 2 diabetes at high risk for these events

• Nausea (11-20%)
• Stomach pain (10-11%)
• Diarrhea (9-10%)
• Lower appetite (6-9%)
• Vomiting (6-8%)
• Constipation (5-6%)

• Risk of thyroid tumors
• Inflammation of the pancreas (pancreatitis)
• Eye problems
• Low blood sugar (hypoglycemia) when taken with certain diabetes medications
• Kidney damage
• Severe stomach side effects
• Severe allergic reactions
• Gallbladder problems
• Lung problems during anesthesia or deep sedation

Saxenda (generic name liraglutide) is a once-daily injection given under the skin that's used for weight loss. It's approved for certain adults and children ages 12 years and up. And it works best when used along with a balanced diet and exercise. This prescription weight loss medication is a glucagon-like peptide-1 (GLP-1) agonist. It works by slowing down your gut and making you feel less hungry. Saxenda (liraglutide) comes as a prefilled pen you use to inject your dose. Some common side effects include nausea, vomiting, and diarrhea.

• Weight loss and long-term weight management in:
  • People ages 12 years and older with a body weight greater than 132 lbs and obesity
  • Adults who are considered overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)

Adults:

• Nausea (39%)
• Diarrhea (21%)
• Constipation (19%)
• Vomiting (16%)
• Injection site reaction (e.g., redness, itching, rash; 14%)
• Headache (14%)
• Low blood sugar in people with Type 2 diabetes (13%)
• Indigestion (10%)

Children 12 years and up:

• Nausea (42%)
• Vomiting (34%)
• Diarrhea (22%)
• Low blood sugar (15%)
• Stomach inflammation (13%)
• Dizziness (10%)

• Possible risk for thyroid cancer
• Inflammation of the pancreas (pancreatitis)
• Gallbladder problems
• Low blood sugar
• Faster heart rate
• Severe stomach side effects
• Kidney problems due to dehydration
• Allergic reactions
• Lung problems during anesthesia or deep sedation