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Compare Rybelsus vs. Ozempic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Rybelsus (semaglutide)
Ozempic (semaglutide)
Rybelsus (semaglutide)
Ozempic (semaglutide)

Summary of Rybelsus vs. Ozempic

Summary for GLP-1 agonist
Prescription only

Rybelsus (semaglutide) is used in combination with diet and exercise to treat type 2 diabetes. While other semaglutide products are injections, Rybelsus (semaglutide) is the only one that's available as a tablet taken by mouth once per day. Common side effects include nausea, vomiting, and diarrhea. The medication also has a warning of potentially raising the risk of developing thyroid tumors or cancer. Rybelsus (semaglutide) is a brand name medication only, so it doesn't have a generic version available.

Summary for GLP-1 agonist
Prescription only

Ozempic (semaglutide) is a prescription injection that's used along with a nutritious diet and exercise to treat Type 2 diabetes in adults. It's also proven to lower the risk of heart attack, stroke, and death due to heart problems in adults with Type 2 diabetes and heart disease. Ozempic (semaglutide) belongs to the drug class known as GLP-1 agonists. The dosing is convenient because it's only injected under the skin once per week. Common side effects of this medication include nausea, vomiting, and diarrhea.

Indications of Rybelsus vs. Ozempic

Indications for
•Type 2 diabetes
Indications for
•Type 2 diabetes
•Lower the risk of heart attack, stroke, and death due to heart problems in adults with Type 2 diabetes and heart disease

Pros and Cons of Rybelsus vs. Ozempic

Pros and Const for GLP-1 agonist
Pros
•Only needs to be taken once per day
•Only medication in its class that comes in a tablet form and doesn't need to be injected
•Comes in three different strengths: 3 mg, 7 mg, and 14 mg
•Can switch between Rybelsus (semaglutide) and Ozempic (semaglutide)
Cons
•Warning for potential risk of thyroid tumors or cancer
•Risk of low blood sugar if taken with certain diabetes medications (e.g., sulfonylureas, insulins)
•Can't be used for type 1 diabetes
•Not a good option for people who've had pancreatitis
Pros and Const for GLP-1 agonist
Pros
•Only given once per week
•Available as prefilled pens for injection
•Can switch injection days as long as the doses are separated by at least 2 days
•Can store open and used pens at room temperature for up to 8 weeks
Cons
•Must be given as an injection under the skin
•Commonly causes nausea, vomiting, and diarrhea
•Risk of low blood sugar if it's taken with certain other diabetes medications (e.g., sulfonylureas, insulins)
•Can't be used for Type 1 diabetes

Common Side Effects of Rybelsus vs. Ozempic

Common Side Effects for
•Nausea (11-20%)
•Stomach pain (10-11%)
•Diarrhea (9-10%)
•Lower appetite (6-9%)
•Vomiting (6-8%)
•Constipation (5-6%)
Common Side Effects for
•Nausea (16-20%)
•Diarrhea (9%)
•Vomiting (5-9%)
•Stomach pain (6-7%)
•Constipation (3-5%)

Warnings of Rybelsus vs. Ozempic

Common Side Effects for
•Thyroid cancer
•Inflammation of the pancreas (pancreatitis)
•Eye problems
•Low blood sugar (hypoglycemia)
•Dehydration and kidney problems
•Severe allergic reactions
•Gallbladder problems
Common Side Effects for
•Thyroid cancer
•Inflammation of the pancreas (pancreatitis)
•Eye problems
•Low blood sugar (hypoglycemia) when taken with certain other diabetes medications
•Dehydration and kidney problems
•Severe allergic reactions
•Gallbladder problems

Prices with our coupons for Rybelsus vs. Ozempic

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