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Compare Rybelsus vs. Glipizide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Rybelsus (semaglutide)
    Glipizide
  • Rybelsus (semaglutide)
    Glipizide

  • Summary of Rybelsus vs. Glipizide

    Summary for GLP-1 agonist
    Prescription only

    Rybelsus (semaglutide) is a brand name glucagon-like peptide-1 (GLP-1) agonist that helps lower blood sugar in adults with Type 2 diabetes. Unlike other medications in this class, it's the first one available as a tablet you take by mouth. The pill is typically taken once a day, at least 30 minutes before you eat, drink, or take any other medications by mouth. It’s used along with diet and exercise, and might also help with weight loss. Common side effects include nausea, stomach pain, and diarrhea.

    Summary for Sulfonylurea
    Prescription only

    Glipizide is a sulfonylurea medication used to treat Type 2 diabetes in adults. It lowers blood sugar levels by telling your pancreas to release more insulin. Glipizide is taken by mouth, typically once or twice daily. Some side effects of this medication include dizziness and diarrhea. Taking glipizide can also put you at risk for dangerously low blood sugar, so it's important to take this medication with meals.

  • Indications of Rybelsus vs. Glipizide

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Rybelsus vs. Glipizide

    Pros and Const for GLP-1 agonist
    Pros
    •Only needs to be taken once per day
    •First GLP-1 agonist in pill form
    •Helps lower blood sugar and might also support weight loss
    Cons
    •Must be taken on an empty stomach
    •Stomach side effects like nausea, diarrhea, and stomach pain are common
    •Can't be used for Type 1 diabetes
    Pros and Const for Sulfonylurea
    Pros
    •Taken by mouth
    •Extended-release tablets taken once daily
    •Available as a lower-cost generic medication
    Cons
    •Raises your risk for low blood sugar levels (hypoglycemia)
    •Need to take with meals or 30 minutes before a meal
    •Can cause some weight gain as a side effect

  • Common Side Effects of Rybelsus vs. Glipizide

    Common Side Effects for
    •Nausea (11-20%)
    •Stomach pain (10-11%)
    •Diarrhea (9-10%)
    •Lower appetite (6-9%)
    •Vomiting (6-8%)
    •Constipation (5-6%)
    Common Side Effects for
    •Dizziness (7%)
    •Diarrhea (5%)
    •Nervousness (4%)
    •Tremor (4%)
    •Passing gas (3%)
    •Low blood sugar levels (3%)

    Note: Side effects were reported by people who took glipizide ER (Glucotrol XL) in clinical studies.

  • Warnings of Rybelsus vs. Glipizide

    Common Side Effects for
    •Risk of thyroid tumors
    •Inflammation of the pancreas (pancreatitis)
    •Eye problems
    •Low blood sugar (hypoglycemia) when taken with certain diabetes medications
    •Kidney damage
    •Severe stomach side effects
    •Severe allergic reactions
    •Gallbladder problems
    •Lung problems during anesthesia or deep sedation
    Common Side Effects for
    •Low blood sugar levels
    •Risk of low red blood cell count (hemolytic anemia)
    •Possible risk of serious heart problems
    •Risk of harm in people with certain stomach problems (extended-release tablets)

  • Prices with our coupons for Rybelsus vs. Glipizide

    Learn more about Rybelsus
    Learn more about Glipizide

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