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Compare Farxiga vs. Wegovy

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Dapagliflozin (Farxiga) and semaglutide (Wegovy) are both medications used to help manage conditions related to diabetes and heart health, but they belong to different medication classes and have distinct uses. Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor taken orally once a day, primarily used to lower blood sugar in people with Type 2 diabetes and to reduce the risk of heart failure and kidney problems. It is available in both brand-name and generic forms. Common side effects include urinary tract infections, yeast infections, and increased urination. Semaglutide, on the other hand, is a glucagon-like peptide-1 (GLP-1) receptor agonist administered as a weekly injection, mainly used for long-term weight management and to lower the risk of heart problems in people with a larger body size. It is not available in a generic form. Other forms of semaglutide (Ozempic, Rybelsus) are used to treat Type 2 diabetes. Common side effects include nausea, diarrhea, and stomach pain. While both medications can interact with other diabetes treatments, dapagliflozin has specific interactions with diuretics and lithium.

Farxiga (dapagliflozin)
Wegovy (semaglutide)
Farxiga (dapagliflozin)
Wegovy (semaglutide)
Summary of Farxiga vs. Wegovy
Summary for SGLT2 inhibitor
Prescription only
Farxiga, the brand name for dapagliflozin, is used together with a nutritious diet and exercise plan to lower blood sugar levels in people 10 years and older with Type 2 diabetes. It can also help lower the risk of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Farxiga (dapagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's taken by mouth once a day. Some side effects include yeast infections, urinating more often, and weight loss.
Summary for GLP-1 agonist
Prescription only
Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist. It's an injection that's given under the skin. The medication is used along with a lower-calorie diet and regular exercise. Wegovy (semaglutide) is approved to help with weight loss in certain adults and children 12 years and over. It also helps lower the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease. And, it's also approved for certain adults with a liver problem called metabolic dysfunction-associated steatohepatitis (MASH). The dosing schedule is an injection once a week. Common side effects are nausea, diarrhea, and stomach pain.
Indications of Farxiga vs. Wegovy
Indications for

•Type 2 diabetes (in addition to diet and exercise) in people age 10 and over

•Lowering the risk of hospitalization for heart failure in adults with Type 2 diabetes and heart disease

•Lowering the risk of hospitalization and death due to heart problems in people with heart failure

•Lowering the risk of worsening kidney problems, hospitalization for heart failure, and death due to heart problems in adults with chronic kidney disease (CKD)

Indications for

•
Weight loss and long-term weight management in:

•People ages 12 years and older who are considered obese

•Adults considered overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)

•
Lowering the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease

•
Metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate-to-advanced liver scarring, but not cirrhosis
Pros and Cons of Farxiga vs. Wegovy
Pros and Const for SGLT2 inhibitor
Pros

•Taken only once daily

•Low risk of causing low blood sugar when taken by itself

•Can take with other diabetes medications

Cons

•Raises risk of yeast infections and urinary tract infections (UTIs)

•Not available as a liquid

•Not recommended during the second and third trimesters of pregnancy

Pros and Const for GLP-1 agonist
Pros

•Can help you lose weight when it's used along with a nutritious diet and regular exercise

•Approved for helping with weight loss for children ages 12 years and older considered obese

•Injected once a week

Cons

•Must inject under the skin

•Can cause stomach pain, nausea, and diarrhea

•Can't take with other semaglutide products (Ozempic, Rybelsus) or with other GLP-1 agonists
Common Side Effects of Farxiga vs. Wegovy
Common Side Effects for

•Vaginal yeast infection in females (7-8%)

•Nose and throat infection (6-7%)

•Urinary tract infection (UTI, 4-6%)

Common Side Effects for

•Nausea (44%)

•Diarrhea (30%)

•Vomiting (24%)

•Constipation (24%)

•Stomach pain (20%)

•Headache (14%)

•Tiredness (11%)
Warnings of Farxiga vs. Wegovy
Common Side Effects for

•Ketoacidosis

•Low fluids in the body (leading to low blood pressure or dehydration)

•Genital and urinary tract infections

•Low blood sugar (hypoglycemia) when used with other diabetes medications

Common Side Effects for

•Possible risk for thyroid cancer

•Inflammation of the pancreas (pancreatitis)

•Gallbladder problems

•Low blood sugar

•Kidney damage

•Allergic reactions

•Eye problems in people with Type 2 diabetes (diabetic retinopathy)

•Faster heart rate

•Possible risk of self-harm

•Lung problems during general anesthesia or deep sedation
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Key takeaways

Summary of Farxiga vs. Wegovy

Indications of Farxiga vs. Wegovy

Pros and Cons of Farxiga vs. Wegovy

Common Side Effects of Farxiga vs. Wegovy

Warnings of Farxiga vs. Wegovy

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