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Compare Wegovy vs. Ozempic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Wegovy (semaglutide)
Ozempic (semaglutide)
Wegovy (semaglutide)
Ozempic (semaglutide)

Summary of Wegovy vs. Ozempic

Summary for GLP-1 agonist
Prescription only

Wegovy (semaglutide) is used in addition to a lower-calorie diet and exercise plan to help with weight loss in certain adults and children 12 years of age and older. It's also proven to lower the risk for heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease. This medication belongs to the drug class called glucagon-like peptide-1 (GLP-1) receptor agonists. The dosing schedule for Wegovy (semaglutide) is once a week, and the medication is injected under your skin. Common side effects include nausea, diarrhea, and stomach pain.

Summary for GLP-1 agonist
Prescription only

Ozempic (semaglutide) is a prescription injection that's used along with a nutritious diet and exercise to treat Type 2 diabetes in adults. It's also proven to lower the risk of heart attack, stroke, and death due to heart problems in adults with Type 2 diabetes and heart disease. Ozempic (semaglutide) belongs to the drug class known as GLP-1 agonists. The dosing is convenient because it's only injected under the skin once per week. Common side effects of this medication include nausea, vomiting, and diarrhea.

Indications of Wegovy vs. Ozempic

Indications for
•Long-term treatment for weight management in:
•Adults with a body mass index (BMI) of 30 kg/m2 or greater; or BMI of 27 kg/m2 or greater and a weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)
•Children 12 years of age and older with a baseline BMI at the 95th percentile or greater
•Lowering the risk of heart attack, stroke, and death due to heart problems in adults with heart disease and a larger body size
Indications for
•Type 2 diabetes
•Lower the risk of heart attack, stroke, and death due to heart problems in adults with Type 2 diabetes and heart disease

Pros and Cons of Wegovy vs. Ozempic

Pros and Const for GLP-1 agonist
Pros
•Can help you lose weight when it's used along with a nutritious diet and regular exercise
•Approved for use for weight loss in certain children aged 12 years and older (BMI at or above the 95th percentile)
•Injected once a week
Cons
•Must inject under the skin
•Can cause stomach pain, nausea, and diarrhea
•Can't take with other semaglutide products (Ozempic, Rybelsus) or with other GLP-1 agonists
Pros and Const for GLP-1 agonist
Pros
•Only given once per week
•Available as prefilled pens for injection
•Can switch injection days as long as the doses are separated by at least 2 days
•Can store open and used pens at room temperature for up to 8 weeks
Cons
•Must be given as an injection under the skin
•Commonly causes nausea, vomiting, and diarrhea
•Risk of low blood sugar if it's taken with certain other diabetes medications (e.g., sulfonylureas, insulins)
•Can't be used for Type 1 diabetes

Common Side Effects of Wegovy vs. Ozempic

Common Side Effects for
•Nausea (44%)
•Diarrhea (30%)
•Vomiting (24%)
•Constipation (24%)
•Stomach pain (20%)
•Headache (14%)
•Tiredness (11%)
Common Side Effects for
•Nausea (16-20%)
•Diarrhea (9%)
•Vomiting (5-9%)
•Stomach pain (6-7%)
•Constipation (3-5%)

Warnings of Wegovy vs. Ozempic

Common Side Effects for
•Possible risk for thyroid cancer
•Inflammation of the pancreas (pancreatitis)
•Gallbladder problems
•Low blood sugar
•Kidney damage
•Allergic reactions
•Eye problems in people with Type 2 diabetes (diabetic retinopathy)
•Faster heart rate
•Possible risk for self-harm
Common Side Effects for
•Thyroid cancer
•Inflammation of the pancreas (pancreatitis)
•Eye problems
•Low blood sugar (hypoglycemia) when taken with certain other diabetes medications
•Dehydration and kidney problems
•Severe allergic reactions
•Gallbladder problems

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