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Compare Zepbound vs. Mounjaro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Zepbound (tirzepatide)
    Mounjaro (tirzepatide)
  • Zepbound (tirzepatide)
    Mounjaro (tirzepatide)

  • Summary of Zepbound vs. Mounjaro

    Summary for GIP and GLP-1 agonist
    Prescription only

    Zepbound, a brand name for tirzepatide, is an injectable medication that's used along with diet and exercise to help with weight loss. It's approved for certain adults who meet criteria for weight management therapy. Zepbound (tirzepatide) is also approved to treat moderate-to-severe sleep apnea. This medication belongs to the drug class called GIP and GLP-1 agonists. The typical dosage is 1 injection under the skin once per week. Common side effects include nausea, diarrhea, stomach pain, and injection site reactions.

    Summary for GIP and GLP-1 agonist
    Prescription only

    Mounjaro (tirzepatide) is a prescription injection that's used together with diet and exercise to improve blood sugar control in adults with Type 2 diabetes. Mounjaro (tirzepatide) was approved by the FDA in May 2022 as the first one in a new class of medications called GIP and GLP-1 agonists. The dosage is convenient because it's injected under the skin once a week. Some common side effects of Mounjaro (tirzepatide) include nausea, vomiting, and diarrhea.

  • Indications of Zepbound vs. Mounjaro

    Indications for

    In addition to diet and exercise:

    •Weight loss and long-term weight management in adults considered obese or overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes)
    •Moderate-to-severe obstructive sleep apnea (OSA) in adults considered obese
    Indications for
    •Type 2 diabetes, in addition to diet and exercise

  • Pros and Cons of Zepbound vs. Mounjaro

    Pros and Const for GIP and GLP-1 agonist
    Pros
    •Injected once weekly
    •Can take with or without food
    •Different strengths available
    •Can store at room temperature for up to 21 days (3 weeks) if needed
    Cons
    •Can cause bothersome side effects, like nausea, diarrhea, and stomach pain
    •Only available as an injection
    •Has many potential interactions, including with certain diabetes medications, warfarin (Coumadin), and birth control pills
    •Not recommended during pregnancy
    Pros and Const for GIP and GLP-1 agonist
    Pros
    •Given once weekly
    •Lowers A1C (average blood sugar over time) by up to 2.4% on average
    •Injections can be given with or without food
    •Comes as ready-to-use injectable pens with a pre-attached needle
    •Can use if you have liver or kidney problems
    Cons
    •Only available as an injection
    •Can cause unpleasant stomach side effects (e.g., nausea, vomiting, diarrhea)
    •Available as brand name only
    •Not approved for children
    •Might not be safe during pregnancy

  • Common Side Effects of Zepbound vs. Mounjaro

    Common Side Effects for
    •Nausea (25-29%)
    •Diarrhea (19-23%)
    •Constipation (11-17%)
    •Vomiting (8-13%)
    •Stomach pain (9-10%)
    •Indigestion (9-10%)
    Common Side Effects for
    •Nausea (12-18%)
    •Diarrhea (12-17%)
    •Low appetite (5-11%)
    •Vomiting (5-9%)
    •Stomach upset or indigestion (5-8%)
    •Constipation (6-7%)
    •Stomach pain (5-6%)

  • Warnings of Zepbound vs. Mounjaro

    Common Side Effects for
    •Risk of thyroid cancer
    •Stomach problems
    •Kidney damage
    •Gallbladder problems
    •Inflammation of the pancreas (pancreatitis)
    •Allergic reactions
    •Low blood sugar (hypoglycemia)
    •Worsened eye problems in people with Type 2 diabetes
    •Suicidal thoughts and behavior
    •Possible risks during general anesthesia
    Common Side Effects for
    •Risk of thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Low blood sugar (hypoglycemia) when used with other diabetes medications
    •Allergic reactions
    •Stomach problems
    •Kidney damage
    •Eye problems related to high blood sugar (complications of diabetic retinopathy)
    •Gallbladder problems

  • Prices with our coupons for Zepbound vs. Mounjaro

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    Learn more about Mounjaro

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