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Compare Zepbound vs. Mounjaro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tirzepatide, marketed under the brand names Zepbound and Mounjaro, is the same medication used to treat different conditions. Both Zepbound and Mounjaro belong to the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist class and are administered via subcutaneous injection once a week. However, they are approved for different uses. Zepbound is FDA-approved for weight loss and long-term weight management in adults who have obesity or who have overweight with at least one weight-related condition, as well as for moderate-to-severe obstructive sleep apnea. On the other hand, Mounjaro is approved for improving blood sugar control in adults with Type 2 diabetes. Both medications share common side effects like nausea and diarrhea. Additionally, both medications can interact with other drugs, such as diabetes medications, warfarin (Jantoven, Coumadin) and birth control pills, potentially affecting their effectiveness. Neither medication is recommended during pregnancy, and both carry a risk of thyroid cancer.

Zepbound (tirzepatide)
Mounjaro (tirzepatide)
Zepbound (tirzepatide)
Mounjaro (tirzepatide)
Summary of Zepbound vs. Mounjaro
Summary for GIP and GLP-1 agonist
Prescription only
Zepbound (tirzepatide) is an injectable medication that's used along with diet and exercise. It helps with weight loss in adults who meet criteria for weight management therapy. It's also approved to treat moderate-to-severe sleep apnea. This medication belongs to the drug class called GIP and GLP-1 agonists. The dosage is 1 injection under the skin once a week. Common side effects include nausea, diarrhea, and injection site reactions. Zepbound (tirzepatide) is only available as a brand-name medication.
Summary for GIP and GLP-1 agonist
Prescription only
Mounjaro (tirzepatide) is a prescription injection used to improve blood sugar control in people 10 years and older with Type 2 diabetes. It works best when you also follow a nutritious diet and exercise regularly. Mounjaro (tirzepatide) belongs to the drug class called GIP and GLP-1 agonists. The dosage is convenient because it's injected under the skin once a week. Some common side effects of Mounjaro (tirzepatide) include nausea and diarrhea. It can also lower your appetite, which might lead to some weight loss.
Indications of Zepbound vs. Mounjaro
Indications for
In addition to a balanced diet and exercise plan:

•Weight loss and long-term weight management in adults considered obese or overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes)

•Moderate-to-severe obstructive sleep apnea (OSA) in adults considered obese

Indications for

•Type 2 diabetes in adults and children 10 years of age and older
Pros and Cons of Zepbound vs. Mounjaro
Pros and Const for GIP and GLP-1 agonist
Pros

•Injected once a week

•Can take with or without food

•Different strengths available, so it's adjustable depending on your needs

Cons

•Must be injected under the skin

•Can cause bothersome side effects, like nausea, diarrhea, and stomach pain

•Can't use with other tirzepatide products (Mounjaro) or with other GLP-1 agonists

Pros and Const for GIP and GLP-1 agonist
Pros

•Given once weekly

•Can lower A1C by an average of up to 2.3% in about 9 months

•Comes in vials and ready-to-use injectable pens

•Can use if you have liver or kidney problems

Cons

•Only available as an injection given under the skin

•Can cause unpleasant side effects like nausea, vomiting, and diarrhea

•Takes time to reach a dose that works well

•Might not be safe during pregnancy
Common Side Effects of Zepbound vs. Mounjaro
Common Side Effects for

•Nausea (25-29%)

•Diarrhea (19-23%)

•Constipation (11-17%)

•Vomiting (8-13%)

•Stomach pain (9-10%)

•Indigestion (9-10%)

Common Side Effects for

•Nausea (12-18%)

•Diarrhea (12-17%)

•Low appetite (5-11%)

•Vomiting (5-9%)

•Indigestion (5-8%)

•Constipation (6-7%)

•Stomach pain (5-6%)
Warnings of Zepbound vs. Mounjaro
Common Side Effects for

•Risk of thyroid cancer

•Stomach problems

•Kidney damage

•Gallbladder problems

•Inflammation of the pancreas (pancreatitis)

•Allergic reactions

•Low blood sugar (hypoglycemia)

•Eye problems in people with Type 2 diabetes (diabetic retinopathy)

•Possible risk of suicidal thoughts and behavior

•Lung problems during general anesthesia or deep sedation

Common Side Effects for

•Risk of thyroid cancer

•Inflammation of the pancreas (pancreatitis)

•Low blood sugar (hypoglycemia) when used with other diabetes medications

•Allergic reactions

•Stomach side effects

•Kidney damage due to dehydration

•Eye problems in people with diabetic retinopathy

•Gallbladder problems

•Lung problems during general anesthesia or deep sedation
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Compare Zepbound vs. Mounjaro

Key takeaways

Summary of Zepbound vs. Mounjaro

Indications of Zepbound vs. Mounjaro

Pros and Cons of Zepbound vs. Mounjaro

Common Side Effects of Zepbound vs. Mounjaro

Warnings of Zepbound vs. Mounjaro

Prices with our coupons for Zepbound vs. Mounjaro

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