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Compare Contrave vs. Mounjaro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Contrave (naltrexone / bupropion)
    Mounjaro (tirzepatide)
  • Contrave (naltrexone / bupropion)
    Mounjaro (tirzepatide)

  • Summary of Contrave vs. Mounjaro

    Summary for Opioid antagonist / Dopamine and norepinephrine reuptake inhibitor
    Prescription only

    Contrave (naltrexone / bupropion) is used along with a lower-calorie diet and exercise routine to help with weight loss for certain adults. This combination medication is a tablet that's taken by mouth. The dosage is slowly raised over the first 3 weeks of treatment until you reach the maintenance dosage of two tablets twice daily. Common side effects include nausea, constipation, and headache. But it can also have more serious risks, such as unusual changes in behavior.

    Summary for GIP and GLP-1 agonist
    Prescription only

    Mounjaro (tirzepatide) is a prescription injection that's used together with diet and exercise to improve blood sugar control in adults with Type 2 diabetes. Mounjaro (tirzepatide) was approved by the FDA in May 2022 as the first one in a new class of medications called GIP and GLP-1 agonists. The dosage is convenient because it's injected under the skin once a week. Some common side effects of Mounjaro (tirzepatide) include nausea, vomiting, and diarrhea.

  • Indications of Contrave vs. Mounjaro

    Indications for
    •Long-term treatment for weight management in adults with a body mass index (BMI) of 30 kg/m2 or greater; or BMI of 27 kg/m2 or greater and a weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)
    Indications for
    •Type 2 diabetes, in addition to diet and exercise

  • Pros and Cons of Contrave vs. Mounjaro

    Pros and Const for Opioid antagonist / Dopamine and norepinephrine reuptake inhibitor
    Pros
    •Is a tablet that's taken by mouth
    •Can see results in as early as 4 weeks (when it's taken along with a balanced diet and regular exercise)
    •Combines 2 different medications into a single pill to help with weight
    Cons
    •Must take twice a day (after the dose ramp-up at the beginning)
    •Might raise your risk for unusual behavior and thoughts of self-harm
    •Not available as a lower-cost generic
    Pros and Const for GIP and GLP-1 agonist
    Pros
    •Given once weekly
    •Lowers A1C (average blood sugar over time) by up to 2.4% on average
    •Injections can be given with or without food
    •Comes as ready-to-use injectable pens with a pre-attached needle
    •Can use if you have liver or kidney problems
    Cons
    •Only available as an injection
    •Can cause unpleasant stomach side effects (e.g., nausea, vomiting, diarrhea)
    •Available as brand name only
    •Not approved for children
    •Might not be safe during pregnancy

  • Common Side Effects of Contrave vs. Mounjaro

    Common Side Effects for
    •Nausea (33%)
    •Constipation (19%)
    •Headache (18%)
    •Vomiting (11%)
    •Dizziness (10%)
    •Trouble sleeping (9%)
    •Dry mouth (8%)
    •Diarrhea (7%)
    Common Side Effects for
    •Nausea (12-18%)
    •Diarrhea (12-17%)
    •Low appetite (5-11%)
    •Vomiting (5-9%)
    •Stomach upset or indigestion (5-8%)
    •Constipation (6-7%)
    •Stomach pain (5-6%)

  • Warnings of Contrave vs. Mounjaro

    Common Side Effects for
    •Suicidal thoughts and behavior
    •Changes in thoughts, behavior, and mood
    •Seizures
    •Don't take Contrave with opioid medications
    •High blood pressure and fast heart rate
    •Liver problems
    •Extreme enthusiasm or excitement (mania)
    •Worsening of glaucoma
    •Potential risk for low blood sugar in certain people with Type 2 diabetes
    Common Side Effects for
    •Risk of thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Low blood sugar (hypoglycemia) when used with other diabetes medications
    •Allergic reactions
    •Stomach problems
    •Kidney damage
    •Eye problems related to high blood sugar (complications of diabetic retinopathy)
    •Gallbladder problems

  • Prices with our coupons for Contrave vs. Mounjaro

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