Compare Trintellix vs. Wellbutrin XL

Trintellix (vortioxetine) and Wellbutrin (bupropion) are both atypical antidepressants, but they work in different ways and have different uses. Trintellix primarily boosts serotonin levels in the brain and is used to treat depression in adults. It is taken once daily and can start to show benefits in as early as two weeks, though full effects may take a month. Common side effects include nausea and diarrhea, and it can cause sexual problems, though less frequently than other antidepressants. On the other hand, Wellbutrin affects norepinephrine and dopamine levels and is used to treat both depression and seasonal affective disorder. It comes in various forms, including short-acting tablets taken multiple times a day and long-acting versions taken once daily. Wellbutrin is less likely to cause sexual side effects and weight gain but is not suitable for individuals with a history of seizures or eating disorders. Additionally, Wellbutrin is available in lower-cost generic forms, whereas Trintellix is only available as a brand-name medication.