Atypical antidepressants are used to treat depression, seasonal affective disorder, and more. These medications work by affecting various neurotransmitters, such as serotonin, norepinephrine, and dopamine. This is thought to improve your mood and reduce anxiety. Atypical antidepressants come as oral pills. Examples include bupropion (Wellbutrin XL, Wellbutrin SR, Aplenzin, Forfivo XL), trazodone, and vortioxetine (Trintellix).