Compare Trintellix vs. Celexa

Trintellix (vortioxetine) and Celexa (citalopram) are both used to treat depression in adults, but they belong to different classes of medications. Trintellix is an atypical antidepressant, while Celexa is a selective serotonin reuptake inhibitor (SSRI). Trintellix works by boosting serotonin action in the brain, though its exact mechanism isn't fully understood. Celexa, on the other hand, increases serotonin levels by preventing its reuptake. Trintellix is only available as a brand-name medication, whereas Celexa has a lower-cost generic form called citalopram. Both medications are taken once daily and can cause side effects like nausea, but Trintellix is less likely to cause weight gain compared to other antidepressants. Celexa can cause serious heart rhythm problems, which is not a noted risk for Trintellix.