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Compare Trintellix vs. Cymbalta

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Trintellix (vortioxetine) and Cymbalta (duloxetine) are both medications used to treat depression, but they belong to different drug classes. Trintellix is an atypical antidepressant, while Cymbalta is an SNRI (serotonin and norepinephrine reuptake inhibitor). Trintellix is taken once daily and is not available in a generic form, whereas Cymbalta can be taken once or twice daily and is available as a lower-cost generic. Trintellix primarily affects serotonin levels, while Cymbalta affects both serotonin and norepinephrine, making it useful for treating anxiety and various types of long-term pain, including diabetic neuropathy and fibromyalgia. Both medications can cause nausea and have a risk of withdrawal symptoms if stopped abruptly, but Cymbalta also has a higher risk of liver damage and can affect blood pressure. Trintellix might be less likely to cause weight gain compared to other antidepressants, while Cymbalta can cause either weight gain and weight loss.

  • Trintellix (vortioxetine)
    Duloxetine (Cymbalta)
  • Trintellix (vortioxetine)
    Duloxetine (Cymbalta)

  • Summary of Trintellix vs. Cymbalta

    Summary for Atypical antidepressant
    Prescription only

    Trintellix (vortioxetine) belongs to a drug class known as atypical antidepressants. It's used to treat depression in adults. This medication is taken by mouth once a day. Some common side effects of Trintellix (vortioxetine) include nausea and diarrhea. It can also cause sexual problems, but not as much as some other antidepressants.

    Summary for SNRI
    Prescription only

    Duloxetine (Cymbalta) is used to treat depression, anxiety, and some forms of long-term pain. This medication is an antidepressant that's called an SNRI or serotonin and norepinephrine reuptake inhibitor. The dosage is typically one capsule by mouth once daily (or twice daily for some people with depression). Side effects can include nausea, headache, and dry mouth. If you need to stop the medication for any reason, your prescriber will lower your dose slowly over time to prevent withdrawal symptoms like anxiety and trouble sleeping.

  • Indications of Trintellix vs. Cymbalta

    Indications for
    •Depression
    Indications for
    •Major depressive disorder in adults
    •Generalized anxiety disorder in people age 7 years and older
    •Diabetic neuropathy (nerve pain caused by high blood sugar) in adults
    •Fibromyalgia in people age 13 years and older
    •Long-term pain in the muscles, bones, joints, or tendons in adults

  • Pros and Cons of Trintellix vs. Cymbalta

    Pros and Const for Atypical antidepressant
    Pros
    •Can start to improve depression in as early as 2 weeks
    •Only needs to be taken once a day
    •Might be less likely to cause weight gain compared to other antidepressants
    Cons
    •Can take up to a month before you feel the full effects
    •Not available as a lower-cost generic
    •Not approved for use in children
    Pros and Const for SNRI
    Pros
    •Can treat several conditions, so might be good for people with multiple conditions
    •Helps lower nerve pain from diabetes and other forms of long-term pain
    •Can take at any time of day (as long as you're consistent)
    •Available as a lower-cost generic
    Cons
    •Can take several weeks before you feel the full effects of the medication on your mood
    •Might not be a good option for people who drink heavily or have liver or kidney problems
    •Can cause higher risk of suicidal thoughts and behavior in people 24 years and younger
    •Might raise your risk of bleeding

  • Common Side Effects of Trintellix vs. Cymbalta

    Common Side Effects for
    •Nausea (21-32%)
    •Diarrhea (7-10%)
    •Dizziness (6-9%)
    •Dry mouth (6-8%)
    •Vomiting (3-6%)
    •Constipation (3-6%)
    Common Side Effects for
    •Nausea (23%)
    •Headache (14%)
    •Dry mouth (13%)
    •Drowsiness (10%)
    •Feeling tired (9%)
    •Trouble sleeping (9%)
    •Dizziness (9%)
    •Constipation (9%)
    •Diarrhea (9%)
    •Low appetite (7%)
    •A lot of sweating (6%)
    •Stomach pain (5%)

  • Warnings of Trintellix vs. Cymbalta

    Common Side Effects for
    •Suicidal thoughts or behavior
    •Serotonin syndrome
    •Risk of bleeding
    •Not for use alone in bipolar disorder
    •Withdrawal symptoms
    •Low blood sodium levels
    •Glaucoma
    •Sexual problems
    Common Side Effects for
    •Suicidal thoughts and behavior
    •Liver damage
    •Changes in blood pressure and risk of falls
    •Serotonin syndrome
    •Higher bleeding risk
    •Severe skin reaction
    •Withdrawal symptoms
    •Mania
    •Low sodium levels
    •Sexual problems

  • Prices with our coupons for Trintellix vs. Cymbalta

    Learn more about Trintellix
    Learn more about Duloxetine

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