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Compare Imitrex vs. Effexor XR

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Sumatriptan (Imitrex) and venlafaxine (Effexor) are both prescription medications, but they are used for different conditions and belong to different drug classes. Sumatriptan (Imitrex) is a triptan used to treat migraines in adults, while Venlafaxine (Effexor) is an SNRI used to treat depression, anxiety, social anxiety disorder, and panic disorder. Sumatriptan works by tightening blood vessels in the brain and reducing inflammation, whereas Venlafaxine increases serotonin and norepinephrine activity to help adjust your mood. Sumatriptan is typically taken as needed for migraines, with a maximum of two doses in 24 hours, while Venlafaxine is taken daily, with doses adjusted based on the condition being treated. Sumatriptan can cause side effects like tingling, numbness, and fatigue, and has serious risks like heart problems and serotonin syndrome. Venlafaxine can cause nausea, tiredness, and dry mouth, and has risks like suicidal thoughts and severe withdrawal symptoms if stopped suddenly. Both medications are available in lower-cost generic forms.

  • Sumatriptan (Imitrex)
    Venlafaxine
  • Sumatriptan (Imitrex)
    Venlafaxine

  • Summary of Imitrex vs. Effexor XR

    Summary for Triptan
    Prescription only

    Sumatriptan (Imitrex) is used to treat migraines with or without aura in adults. The medication is typically taken as a single dose for your migraine. But, it's possible that you can take it again 2 hours after the first dose if your migraine doesn't go away. Side effects of sumatriptan (Imitrex) include tingling or numbness of fingers or toes, feeling too warm or too cold, and fatigue. It can interact with antidepressants and other similar migraine medications. Sumatriptan (Imitrex) is available as a lower-cost generic tablet.

    Summary for SNRI
    Prescription only

    Venlafaxine is an antidepressant used to treat mental health conditions like depression, generalized anxiety disorder, social anxiety disorder, and panic disorder. It comes in two forms: extended-release, which is taken once a day, and immediate-release, which is taken in split doses throughout the day. This medication can interact with many things, including other medications and alcohol. Possible side effects can include nausea, weight changes, and sexual problems. It can also cause withdrawal symptoms if you stop taking it suddenly.

  • Indications of Imitrex vs. Effexor XR

    Indications for
    •Treatment of migraine attacks with or without aura in adults
    Indications for
    •Depression
    •Generalized anxiety disorder - extended-release capsules only
    •Social anxiety disorder - extended-release capsules and tablets only
    •Panic disorder - extended-release capsules only

  • Pros and Cons of Imitrex vs. Effexor XR

    Pros and Const for Triptan
    Pros
    •First-choice option for treating migraines
    •Can take with commonly used over-the-counter pain relievers like acetaminophen (Tylenol)
    •Can start relieving migraine headaches within 30 minutes to 2 hours
    •Available as a lower-cost generic
    Cons
    •Can't use to prevent migraines
    •Must wait at least 2 hours after the first dose to take a second dose, if needed
    •Your migraines can get worse if you use this medication too often.
    •Unknown if it's safe or if it works well in children
    Pros and Const for SNRI
    Pros
    •Can treat multiple mental health conditions
    •Affects two chemicals in the brain that impact your mood
    •Lower risk of weight gain compared to other antidepressants
    •Comes in both immediate-release and extended-release versions
    Cons
    •Might raise your blood pressure, especially at higher doses
    •Interacts with many medications
    •Can take up to 4 to 8 weeks before you feel the full effect
    •High risk of causing withdrawal symptoms if suddenly stopped

  • Common Side Effects of Imitrex vs. Effexor XR

    Common Side Effects for
    •Tingling or numbness of fingers or toes (3-5%)
    •Feeling too warm or too cold (2-3%)
    •Fatigue (2-3%)
    Common Side Effects for

    Extended-release:

    •Nausea (29-31%)
    •Trouble sleeping (17-23%)
    •Dizziness (16-20%)
    •Loss of appetite (10-20%)
    •Drowsiness (15-17%)
    •Dry mouth (12-17%)
    •Abnormal ejaculation (10-16%)
    •Sweating (11-14%)
    •Weakness (8-13%)

    Immediate-release:

    •Nausea (37%)
    •Headache (25%)
    •Drowsiness (23%)
    •Dry mouth (22%)
    •Dizziness (19%)
    •Trouble sleeping (18%)
    •Constipation (15%)
    •Nervousness (13%)
    •Weakness (12%)
    •Sweating (12%)
    •Abnormal ejaculation (12%)
    •Loss of appetite (11%)

  • Warnings of Imitrex vs. Effexor XR

    Common Side Effects for
    •Heart problems and high blood pressure
    •Stroke or other brain injury
    •Extreme narrowing of blood vessels
    •Serotonin syndrome
    •Allergic reactions
    •Seizures
    Common Side Effects for
    •Suicidal thoughts and behavior
    •Serotonin syndrome
    •High blood pressure
    •Higher bleeding risk
    •Mania
    •Glaucoma
    •Withdrawal
    •Seizures
    •Low sodium levels
    •Lung problems and pneumonia
    •Sexual problems

  • Prices with our coupons for Imitrex vs. Effexor XR

    Learn more about Sumatriptan
    Learn more about Venlafaxine

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