Key takeaways
Sumatriptan (Imitrex) and naratriptan (Amerge) are both triptans used to treat migraines with or without aura in adults. Sumatriptan is available in various forms, including tablets, injections, and nasal sprays, while naratriptan is only available as a tablet. Sumatriptan can be taken again 2 hours after the first dose if needed, but naratriptan requires a 4-hour wait before a second dose. Sumatriptan starts working within about 2 hours, whereas naratriptan can take up to 3 or 4 hours to reach its maximum effect. Both medications can cause serious issues like heart problems and serotonin syndrome. Sumatriptan is available as a lower-cost generic, and while the brand name Amerge for naratriptan is no longer available, its generic form can still be prescribed.
