Key takeaways
Sumatriptan (Imitrex) and Ergomar (ergotamine) are both used to treat migraines, but they have some key differences. Sumatriptan is a triptan that works by tightening blood vessels and reducing inflammation, while Ergomar is an ergot derivative that also tightens blood vessels but works by calming certain parts of the brain. Sumatriptan is typically taken as a single dose and can be repeated after 2 hours if needed, whereas Ergomar is taken sublingually and can be repeated after 30 minutes. Sumatriptan is available as a lower-cost generic, but Ergomar is not. Ergomar lasts longer than Sumatriptan, reducing the likelihood of a repeat headache. Both medications can cause serious side effects like heart problems and high blood pressure, but Ergomar has additional risks such as causing birth defects and fibrosis with long-term use. You should not take these medications together or within 24 hours of each other due to the risk of dangerously high blood pressure.
