Compare Elavil vs. Imitrex
Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Amitriptyline (formerly branded as Elavil) and sumatriptan (Imitrex) are both prescription medications, but they are used for different purposes and belong to different drug classes. Amitriptyline is a tricyclic antidepressant (TCA) primarily used to treat depression, though it is also used off-label for nerve pain and migraine prevention. On the other hand, sumatriptan (Imitrex) is a triptan used to treat acute migraine attacks with or without aura in adults. Amitriptyline works by increasing levels of serotonin and norepinephrine in the brain to improve mood, while sumatriptan (Imitrex) works by activating serotonin receptors to tighten blood vessels and reduce inflammation and pain. Amitriptyline is taken daily, whereas sumatriptan is taken as needed for migraines, with a maximum of two doses in 24 hours. Common side effects of amitriptyline include sleepiness and weight gain, while sumatriptan can cause tingling, numbness, and fatigue. Both medications are available in generic forms, making them more affordable options.
Summary of Elavil vs. Imitrex
Amitriptyline is FDA approved to treat depression. But it isn't as commonly used today as other antidepressants because it can cause a lot of side effects, such as sleepiness and weight gain. In addition, amitriptyline has many interactions with other medications, including other antidepressants, sedatives, and antihistamines. But despite the side effects and interactions, amitriptyline is often used off label for nerve pain due to diabetes and migraine prevention. While its brand name Elavil is no longer available, amitriptyline is available as a generic medication.
Sumatriptan (Imitrex) is used to treat migraines with or without aura in adults. The medication is typically taken as a single dose for your migraine. But, it's possible that you can take it again 2 hours after the first dose if your migraine doesn't go away. Side effects of sumatriptan (Imitrex) include tingling or numbness of fingers or toes, feeling too warm or too cold, and fatigue. It can interact with antidepressants and other similar migraine medications. Sumatriptan (Imitrex) is available as a lower-cost generic tablet.
Indications of Elavil vs. Imitrex
Pros and Cons of Elavil vs. Imitrex
Common Side Effects of Elavil vs. Imitrex
Warnings of Elavil vs. Imitrex
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