Key takeaways
Amitriptyline (Elavil) and lidocaine viscous (Xylocaine) are both medications that can help with pain, but they work in different ways and are used for different conditions. Amitriptyline is a tricyclic antidepressant (TCA) FDA-approved to treat depression, but is often used off-label for nerve pain and migraine prevention. It is taken orally, usually once a day. Common side effects include sleepiness, weight gain, and dizziness. It can interact with many other medications, such as sedatives and antihistamines. On the other hand, lidocaine viscous is a topical, local anesthetic used to numb painful areas in the mouth and throat, as well as to prevent gagging during dental procedures. Lidocaine viscous can cause side effects like dizziness and drowsiness, and using too much can lead to serious issues like seizures and heart problems. Unlike amitriptyline, lidocaine viscous is not used for depression or nerve pain and does not have the same drug interactions. Both medications are available as a lower-cost generic.
