Compare Elavil vs. Silenor

Amitriptyline (formerly branded as Elavil) and Silenor (doxepin) are both tricyclic antidepressants, but they are used for different purposes. Amitriptyline is primarily FDA approved to treat depression, though it is also used off-label for nerve pain and migraine prevention. In contrast, Silenor is specifically approved to treat insomnia, helping you stay asleep through the night. Amitriptyline can cause a range of side effects, including sleepiness, weight gain, and dizziness, and it has many interactions with other medications. Silenor, on the other hand, is noted for not being addictive and is generally taken once daily before bedtime. However, it can cause sleepiness and unusual behaviors while not fully awake. While both medications can worsen depression or cause suicidal thoughts, this risk is more pronounced in younger individuals. Additionally, Silenor should be taken on an empty stomach, unlike amitriptyline, which can be taken with or without food.