Compare Elavil vs. Fioricet
Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Amitriptyline (formerly branded as Elavil) and Fioricet (butalbital/acetaminophen/caffeine) are both prescription medications, but they serve different purposes and belong to different drug classes. Amitriptyline is a tricyclic antidepressant (TCA) primarily used to treat depression, though it is also used off-label for nerve pain and migraine prevention. In contrast, Fioricet is a combination medication used to treat tension headaches and includes a barbiturate (butalbital), an analgesic (acetaminophen), and caffeine. Amitriptyline is taken daily, while Fioricet is taken as needed, typically every 4 hours. Amitriptyline can cause side effects like sleepiness and weight gain, whereas Fioricet can cause drowsiness, dizziness, and has a risk of misuse and dependence. Additionally, Fioricet can lead to liver damage if taken in excess due to its acetaminophen content. Unlike amitriptyline, Fioricet is controlled in some states because of its potential for dependence. Both medications are available in generic forms, making them more affordable options.
Summary of Elavil vs. Fioricet
Amitriptyline is FDA approved to treat depression. But it isn't as commonly used today as other antidepressants because it can cause a lot of side effects, such as sleepiness and weight gain. In addition, amitriptyline has many interactions with other medications, including other antidepressants, sedatives, and antihistamines. But despite the side effects and interactions, amitriptyline is often used off label for nerve pain due to diabetes and migraine prevention. While its brand name Elavil is no longer available, amitriptyline is available as a generic medication.
Fioricet is a combination medication containing butalbital, acetaminophen, and caffeine. It's taken by mouth as needed, typically every 4 hours, to treat tension headaches. But it's not a first-choice option because it can become habit-forming and can worsen headaches if taken too frequently. In addition, Fioricet can cause side effects, such as sleepiness and dizziness. It's available as pills and an oral syrup.
Indications of Elavil vs. Fioricet
Pros and Cons of Elavil vs. Fioricet
Common Side Effects of Elavil vs. Fioricet
Warnings of Elavil vs. Fioricet
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