Compare Estazolam vs. Doxepin

Estazolam (formerly branded as Prosom) and doxepin (formerly branded as Sinequan) are both prescription medications, but they serve different purposes and belong to different drug classes. Estazolam is a benzodiazepine used for the short-term treatment of insomnia, helping you fall asleep and stay asleep. It is a controlled substance (Schedule IV) due to its potential for misuse and dependence. On the other hand, doxepin is a tricyclic antidepressant (TCA) used to treat depression and anxiety, and it is not a controlled substance. While estazolam works quickly and is taken right before bed, doxepin can take 2 to 3 weeks to show its full effects for depression and is usually taken once daily. Estazolam is only available as a generic tablet, whereas doxepin is also available in different forms, including an oral solution. Both medications can cause drowsiness, but estazolam is specifically noted for causing sleep-related behaviors like sleepwalking and sleep driving, which are not mentioned for doxepin. Additionally, doxepin has a broader range of side effects, including dry mouth and constipation, and carries a risk of worsening depression and suicidal thoughts, especially in younger individuals.