Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Lunesta (eszopiclone) and Butisol (butabarbital) are both medications used to help with sleep, but they have some key differences. Lunesta is a sedative-hypnotic that is available as a generic and is used to treat insomnia by helping you fall asleep faster and stay asleep longer. It is a Schedule IV controlled substance, meaning it has some potential for misuse and dependence. On the other hand, Butisol is a barbiturate that was known for its fast-acting effects but has been discontinued and is no longer available in the U.S. as either a brand or generic medication. Butisol was a Schedule III controlled substance, indicating a higher potential for misuse compared to Lunesta. While Lunesta can cause side effects like a bad taste in the mouth and headache, Butisol was known to be habit-forming and addicting. If you need a sleep aid, Lunesta is still an option, but Butisol is not available anymore.
Lunesta (eszopiclone)
Butisol (butabarbital)
Lunesta (eszopiclone)
Butisol (butabarbital)
Summary of Lunesta vs. Butisol
Summary for Sedative-hypnotic
Prescription only
Lunesta (eszopiclone) is used to treat insomnia in people over the age of 18. This medication can help you fall asleep faster and wake up fewer times during the night. Lunesta (eszopiclone) belongs to a drug class called sedative-hypnotics, and it's a controlled substance so there are restrictions on how it can be filled and refilled at the pharmacy. You typically only need to take a dose right before bedtime, but it can cause a headache or leave a bad taste in your mouth as a side effect.
Summary for Barbiturate
Butisol (butabarbital) is a fast-acting sleep medication. It's not a first choice treatment option and has been discontinued. Both brand and generic options are no longer available in the U.S.