Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Zaleplon (Sonata) and flurazepam (formerly branded as Dalmane) are both medications used to treat insomnia, but they belong to different drug classes and have distinct characteristics. Zaleplon is a non-benzodiazepine sedative-hypnotic that helps you fall asleep quickly but doesn't help you stay asleep. In contrast, flurazepam is a benzodiazepine that helps you both fall asleep and stay asleep throughout the night. Zaleplon is typically used for short-term treatment (up to 30 days) and is available as a lower-cost generic, while flurazepam can be used for up to 28 days and is also available in generic form. Both medications can be habit-forming and may cause dependence, but flurazepam has a higher risk of side effects, especially for females and older adults. Additionally, both medications can cause unusual behaviors like sleepwalking and sleep-driving, but flurazepam has a broader range of common side effects, including headache and upset stomach.
Zaleplon
Flurazepam
Zaleplon
Flurazepam
Summary of Sonata vs. Dalmane
Summary for Sedative-hypnotic
Prescription only
Zaleplon, once sold under the brand name Sonata, is a prescription sleep medication for adults. It helps with insomnia (trouble falling asleep). It's a type of sedative-hypnotic called a non-benzodiazepine, or "z-drug." You take it by mouth right before bed or when you're already in bed and can't fall asleep. Zaleplon is a controlled substance because it has a risk of misuse and dependence. Side effects can include headache and dizziness.
Summary for Benzodiazepine
Prescription only
Flurazepam is used to treat sleeping problems (insomnia). It's a controlled substance because it has a risk for becoming habit-forming. The brand name Dalmane has been discontinued, but it's still available as generic versions. Side effects of the medication include headache and upset stomach.