Key takeaways
Maprotiline and doxepin are both medications used to treat depression and anxiety, but they belong to different classes. Maprotiline was a tetracyclic antidepressant, but is no longer available in the U.S. Doxepin is a tricyclic antidepressant (TCA) that's also FDA-approved for insomnia under the brand name Silenor. The typical dose for doxepin ranges from 75 mg to 150 mg daily. Common side effects of doxepin include drowsiness, dry mouth, and weight gain, and it can cause withdrawal symptoms if stopped abruptly. Doxepin also has specific warnings about worsening depression and suicidal thoughts, especially in people under age 25.
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