Is maprotiline still available?

No, maprotiline has been [discontinued](https://www.ashp.org/drug-shortages/current-shortages/drug-shortage-detail.aspx?id=677&loginreturnUrl=SSOCheckOnly#:~:text=Mylan%20discontinued%20maprotiline%20tablets%20in%20June%202021.) as of June 2021 and is no longer available in the United States. It's not clear why maprotiline has been discontinued. But it probably wasn't commonly used in recent years because there are newer antidepressants on the market that have fewer side effects.

What medications are used in place of maprotiline?

There are several [antidepressants](https://www.goodrx.com/conditions/depression/best-medicine-for-depression-reviews-popular-antidepressants) available that are commonly used today for people with depression or anxiety. Examples include [sertraline (Zoloft)](https://www.goodrx.com/zoloft/what-is), [fluoxetine (Prozac)](https://www.goodrx.com/prozac/what-is), and [citalopram (Celexa)](https://www.goodrx.com/citalopram/what-is). Talk to your provider to see which anxiety or depression medication is right for you.

maprotiline

Generic Ludiomil

Used for Anxiety, Depression

Basics FAQs Dosage Interactions Alternatives References Prices Medicare

Maprotiline is an antidepressant used to treat depression and anxiety associated with depression. It's no longer available in the United States because it was discontinued.

Reviewed by:

Robert Chad Hakim, PharmD, BCCCP

Kristianne Hannemann, PharmD

Last reviewed on January 11, 2023

Basics FAQs Dosage Interactions Alternatives References Prices Medicare

What is Maprotiline?

What is Maprotiline used for?

Depression
Anxiety from depression

Drug facts

Common BrandsLudiomil(brand name no longer available)

Drug ClassTetracyclic antidepressant

Controlled Substance ClassificationNot a controlled medication

Generic StatusNo lower-cost generic available

AvailabilityPrescription only

Common questions about Maprotiline

Maprotiline is a tetracyclic antidepressant used for depression and anxiety associated with depression. It's not entirely known how maprotiline works, but it's thought to raise the amount of norepinephrine in the brain, which is a chemical involved with mood.

No, maprotiline has been discontinued as of June 2021 and is no longer available in the United States. It's not clear why maprotiline has been discontinued. But it probably wasn't commonly used in recent years because there are newer antidepressants on the market that have fewer side effects.

There are several antidepressants available that are commonly used today for people with depression or anxiety. Examples include sertraline (Zoloft), fluoxetine (Prozac), and citalopram (Celexa). Talk to your provider to see which anxiety or depression medication is right for you.

How to save using GoodRx

1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.

2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.

3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.

Get free coupon Learn more

Maprotiline dosage

Typical dosage for Maprotiline

Interactions between Maprotiline and other drugs

Maprotiline may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Maprotiline. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Brofaromine
Bromopride
Clorgyline
Furazolidone
Iproniazid
Isocarboxazid
Lazabemide
Linezolid
Methylene Blue
Moclobemide
Nialamide
Pargyline
Phenelzine
Procarbazine
Rasagiline
Safinamide
Selegiline
Toloxatone
Tranylcypromine

What are alternatives to Maprotiline?

There are a number of medications that your doctor can prescribe in place of Maprotiline. Compare a few possible alternatives below.

Maprotiline

Used for:

Depression
Anxiety from depression

View prices

Fluoxetine (Prozac)

Used for:

$8.39Lowest GoodRx priceView prices

Sertraline (Zoloft)

Used for:

$8.80Lowest GoodRx priceView prices

References

Best studies we found

American Society of Health-System Pharmacists. (2021). Maprotiline tablets.

Mylan Pharmaceuticals Inc. (2014). Maprotiline hydrochloride tablets, USP [package insert].

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

maprotiline