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Post-traumatic stress disorder (PTSD) is a condition that occurs after a traumatic event such as a serious accident, natural disaster, war, sexual assault, or abuse. PTSD can also occur after experiencing an indirect trauma, such as witnessing violence or working as a first responder.
PTSD can present in various ways that may lead to symptoms such as nightmares, flashbacks, insomnia, losing interest in your favorite activities, and intrusive thoughts. It is also closely tied with other mental health conditions, such as anxiety or depression. About 3.5% percent of U.S. adults experience PTSD each year.
This guide will review the causes, symptoms, and treatment options for PTSD.
A wide range of stressful or traumatic events can trigger PTSD, especially situations that make you believe your life is in danger. These include:
Sexual trauma or domestic violence
Mass conflict or displacement
Being exposed to a warzone, military combat, or community violence
A traumatic injury, such as a motor vehicle accident
Medical trauma like a heart attack or stroke
Trauma in childhood, such as physical or sexual abuse
Serving as a first responder or healthcare professional
Many people will experience stressful events and traumas in their lifetime, but not all will go on to have PTSD. There are some known risk factors that can increase your risk of developing PTSD, including:
Young age at the time of the trauma
A history of childhood adversity or abuse
Poor social support
A history of substance use or other mental health issues
Other factors may increase your likelihood for developing PTSD including genetics, hormonal and brain changes, and environmental factors.
Adults with PTSD can have a wide range of symptoms that fall into the following categories:
Intrusion: This includes distressing memories, flashbacks, or nightmares as well as dissociation, which is when you feel detached from your surroundings, experiences, or sense of self.
Avoidance: This includes avoiding any reminders of the traumatic event such as specific people or places.
Cognitive and mood changes: This could be guilt, loss of interest in activities, or the development of depressive symptoms.
Arousal and reactivity: This may include increased irritability, anxiety, paranoia, or difficulty concentrating.
Young children may have different symptoms from PTSD such as:
Beginning to wet the bed after being potty trained
Regressing in verbal skills, such as no longer talking
Reenacting the traumatic event when playing
Having trouble sitting still or paying attention
Older children or teens could also develop aggressive or risky behaviors.
You will need a full psychological evaluation to be diagnosed with PTSD. A healthcare provider will make a diagnosis based on the DSM-5 criteria for PTSD, which includes the following:
Exposure to a traumatic event, which can be direct or indirect trauma.
At least one intrusion symptom such as distressing memories, dreams, or flashbacks.
At least one symptom related to avoiding trauma triggers, such as avoiding people, places, or situations that may remind you of the traumatic event.
At least two symptoms of arousal and reactivity such as irritability or angry outbursts, hypervigilance, difficulty concentrating, or sleep trouble.
At least two mood or cognition symptoms related to the traumatic event such as memory loss, emotions like guilt or fear, or isolating from others.
Your symptoms need to be going on for more than 1 month to receive a PTSD diagnosis. Symptoms must also be severe enough that they affect your relationships or work.
The right PTSD treatment for you will depend on many factors. It’s important to talk with your healthcare provider about the best options for you.
Psychotherapy is a key component of treatment for PTSD. There are different forms of psychotherapy. Some of the most effective therapies for PTSD include:
In addition to psychotherapy, many with PTSD also benefit from medication. The right medication for you will depend on many factors. Some medication options for PTSD include:
Antidepressants including SSRIs or SNRIs such as sertraline (Zoloft), paroxetine (Paxil), or venlafaxine (Effexor)
Prazosin (Minipress), an alpha-adrenergic receptor blocker otherwise used for high blood pressure, to treat PTSD sleep issues like nightmares
Antipsychotics such as quetiapine (Seroquel) or risperidone (Risperdal), which are sometimes added to treatment if antidepressants alone aren’t helping you enough
There isn’t usually a way to prevent a traumatic event from occurring. But there may be protective steps you can take to lower your risk of developing PTSD after a traumatic event. Some of these include:
Having supportive friends or family or attending a support group
Telling your loved ones about the trauma if you feel comfortable
Noticing moments of joy and gratitude in your daily life
Working on finding meaning about the trauma
Finding ways to help others
If you experienced trauma, it may help to monitor how you’re coping afterward to catch any signs of PTSD early. Routine PTSD screening — such as a self-test like My HealtheVet’s PTSD screening — can be helpful.
Alegría, M., et al. (2013). Prevalence, risk, and correlates of posttraumatic stress disorder across ethnic and racial minority groups in the United States. Medical Care.
American Psychiatric Association. (2020). What is posttraumatic stress disorder?
Anxiety and Depression Association of America. (2017). How to prevent trauma from becoming PTSD.
Anxiety and Depression Association of America. (2021). Treatment & facts post-traumatic stress disorder.
Centers for Disease Control and Prevention. (2021). Post-traumatic stress disorder in children.
Center for Substance Abuse Treatment (US). (2014). Exhibit 1.3-4, DSM-5 diagnostic criteria for PTSD. Trauma-Informed Care in Behavioral Health Services.
Kessler, R. C., et al. (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry.
Kroll, J. (2003). Posttraumatic symptoms and the complexity of responses to trauma. JAMA.
Lancaster, C., et al. (2016). Posttraumatic stress disorder: overview of evidence-based assessment and treatment. Journal of Clinical Medicine.
My HealtheVet. PTSD screening.
National Alliance on Mental Illness. (2017). Posttraumatic stress disorder.
National Institute of Mental Health. (2019). Post-traumatic stress disorder.
Rauch, S.A., et al. (2012). Review of exposure therapy: a gold standard for PTSD treatment. Journal of Rehabilitation Research and Development.
Sareen, J. (2014). Posttraumatic stress disorder in adults: impact, comorbidity, risk factors, and treatment. Canadian Journal of Psychiatry.
Substance Abuse and Mental Health Services Administration (SAMHSA). (2021). SAMHSA National Helpline.
U.S. Department of Veterans Affairs. Medications for PTSD.
U.S. Department of Veterans Affairs. PTSD basics.
U.S. Department of Veterans Affairs. PTSD in children and teens.
Watkins, L. E., et al. (2018). Treating PTSD: a review of evidence-based psychotherapy interventions. Frontiers in Behavioral Neuroscience.
Wilson, G., et al. (2018). The use of eye-movement desensitization reprocessing (EMDR) therapy in treating post-traumatic stress disorder — a systematic narrative review. Frontiers in Psychology.
Already take medication for PTSD? Use GoodRx to compare prices for sertraline (Zoloft), paroxetine (Paxil), or venlafaxine (Effexor) at pharmacies near you.