Head-to-head comparisons of medication uses, side effects, warnings, and more.
Maprotiline
Imipramine
Maprotiline
Imipramine
Summary of Maprotiline vs. Tofranil
Summary for Tetracyclic antidepressant
Prescription only
Maprotiline is an antidepressant used to treat depression and anxiety associated with depression. It's no longer available in the United States because it was discontinued.
Summary for Tricyclic antidepressant
Prescription only
Imipramine is a medication that's used to treat depression. It can also temporarily help with bedwetting in children at night. Imipramine belongs to a class of medications called tricyclic antidepressants (TCAs). There are two different forms of the medication: imipramine hydrochloride and imipramine pamoate. They used to be available under the brand name Tofranil but are now only sold as generic versions. The dosage generally depends on why you need imipramine, how severe your symptoms are, and your age. It's generally not a first-choice option because it can cause a lot of side effects, like sleepiness, dizziness, dry mouth, and changes in weight.
Indications of Maprotiline vs. Tofranil
Indications for
•Depression
•Anxiety from depression
Indications for
•Depression
•Bedwetting in children (imipramine hydrochloride only)
Pros and Cons of Maprotiline vs. Tofranil
Pros and Const for Tetracyclic antidepressant
Pros
Cons
Pros and Const for Tricyclic antidepressant
Pros
•Available as a lower-cost generic
•Can take with or without food
•Dose can be adjusted by your provider based on how well the medication is working for you
•For bedwetting, only needs to be taken right before bedtime
Cons
•Can cause a lot of side effects, including blurry vision, dry mouth, and eye pain
•Can cause withdrawal symptoms if you stop taking it too suddenly after long-term use
•Has a risk for suicidal thoughts and behavior
•Not a good option for people with a history of heart problems
Common Side Effects of Maprotiline vs. Tofranil
Common Side Effects for
Common Side Effects for
In adults (with depression)
•Dry mouth
•Blurry vision
•Nausea
•Vomiting
•Constipation
•Sleepiness
•Dizziness
•Confusion
•Anxiety
•Restlessness
In children (with bedwetting problems)
•Nervousness
•Sleep problems
•Tiredness
•Stomach upset
Warnings of Maprotiline vs. Tofranil
Common Side Effects for
Common Side Effects for
•Worsening depression, suicidal thoughts, and unusual behavior
•Not for use alone in bipolar disorder
•Risk of heart problems, heart attack, or stroke
•Glaucoma
•Higher risk of falls
•Seizures
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