Key takeaways
Maprotiline and imipramine are both medications used to treat depression, but they belong to different classes. Maprotiline was a tetracyclic antidepressant, but is no longer available in the U.S. Imipramine is a tricyclic antidepressant (TCA). Imipramine has an additional FDA-approved use for treating bedwetting in children, Imipramine comes in two forms: imipramine hydrochloride tablets and imipramine pamoate capsules, with dosing adjusted based on age and condition. Common side effects of imipramine include dry mouth, dizziness, and weight changes. Imipramine has significant drug interactions, especially with sedatives and MAOIs, and carries risks like suicidal thoughts and heart problems.
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