Key takeaways
Maprotiline and doxepin (Silenor) are both medications used to treat depression and anxiety, but they belong to different classes. Doxepin is a tricyclic antidepressant. It's also FDA-approved to treat insomnia under the brand name Silenor. Maprotiline was a tetracyclic antidepressant, but is no longer available in the U.S. Doxepin is available in both brand-name and generic forms. Doxepin should not be taken with food, as it can delay the medication's effects and increase the risk of daytime sleepiness. Additionally, doxepin has specific contraindications, such as not being taken with monoamine oxidase inhibitors (MAOIs) or by people with narrow-angle glaucoma.
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