Key takeaways
Doxepin (Silenor) and nortriptyline (Pamelor) are both tricyclic antidepressants (TCAs), but they have some important differences. Doxepin is FDA-approved for insomnia, specifically to help you stay asleep, while nortriptyline is approved for treating depression and is also used off-label for nerve pain. Doxepin is typically taken as a tablet once a day before bedtime, whereas nortriptyline can be taken as a capsule or liquid, either once a day or split into smaller doses throughout the day. Doxepin is available as a lower-cost generic, while nortriptyline is available as both a brand-name and generic medication. Common side effects of doxepin include sleepiness and tiredness, while nortriptyline can cause blurred vision, dry mouth, and an upset stomach. Both medications can increase the risk of developing or worsening glaucoma. They may also increase the risk of heart problems.
