Key takeaways
Doxepin (Silenor) and trimipramine are both tricyclic antidepressants, but they are used for different reasons. Doxepin is FDA-approved for treating insomnia, specifically to help you stay asleep, while trimipramine is used to treat depression. The usual doxepin dosage is one 6 mg tablet once daily, 30 minutes before bedtime. In contrast, trimipramine is taken in divided doses throughout the day or as a single dose at bedtime, with a typical dosing range of 50 mg to 150 mg and a maximum of 200 mg daily. Doxepin is available in both brand-name and generic forms, whereas trimipramine is only available as a generic since the brand Surmontil is no longer available. Common side effects of doxepin include sleepiness and tiredness, while trimipramine can cause drowsiness, changes in blood pressure, and dizziness. Both medications can increase the risk of developing or worsening glaucoma. They may also increase the risk of heart problems.
